• Publications
  • Influence
Importing Mitochondrial Proteins: Machineries and Mechanisms
TLDR
Recent insights into the importing and sorting of mitochondrial proteins and their contributions to mitochondrial biogenesis are discussed. Expand
Essential role of Mia40 in import and assembly of mitochondrial intermembrane space proteins
TLDR
The binding of small Tim proteins to Mia40 is crucial for their transport across the outer membrane and represents an initial step in their assembly into IMS complexes. Expand
Mitochondrial Presequence Translocase: Switching between TOM Tethering and Motor Recruitment Involves Tim21 and Tim17
TLDR
The presequence translocase is not a static complex but switches between TOM tethering and PAM binding in a reaction cycle involving Tim21 and Tim17, which is crucial for the switch of protein translocation into the matrix. Expand
Machinery for protein sorting and assembly in the mitochondrial outer membrane
TLDR
The results suggest that the TOM complex, which can transport all kinds of mitochondrial precursor proteins, is not sufficient for the correct integration of outer membrane proteins with a complicated topology, and instead transfers precursor proteins to the SAM complex. Expand
The proteome of Saccharomyces cerevisiae mitochondria
TLDR
The mitochondrial proteome will provide an important database for the analysis of new mitochondrial and mitochondria-associated functions and the characterization of mitochondrial diseases. Expand
Dual role of mitofilin in mitochondrial membrane organization and protein biogenesis.
TLDR
The findings indicate that mitofilin is a central component of MINOS and functions as a multifunctional regulator of mitochondrial architecture and protein biogenesis. Expand
The mitochondrial morphology protein Mdm10 functions in assembly of the preprotein translocase of the outer membrane.
TLDR
It is concluded that Mdm10 plays a specific role in the biogenesis of the TOM complex, indicating a connection between the mitochondrial protein assembly apparatus and the machinery for maintenance of mitochondrial morphology. Expand
The Mitochondrial Presequence Translocase An Essential Role of Tim50 in Directing Preproteins to the Import Channel
TLDR
The essential protein Tim50 is identified, which exposes its major domain to the intermembrane space and is crucial for guiding the precursors of matrix proteins to their insertion site in the inner membrane. Expand
Intermembrane Space Proteome of Yeast Mitochondria*
TLDR
The first and comprehensive proteome of IMS proteins of yeast mitochondria with 51 proteins in total is presented and will serve as a valuable source for further studies on the role of the IMS in cell life and death. Expand
Mistargeted mitochondrial proteins activate a proteostatic response in the cytosol
TLDR
It is proposed that this type of unfolded protein response activated by mistargeting of proteins (UPRam) is beneficial for the cells and provides a means for buffering the consequences of physiological slowdown in mitochondrial protein import and for counteracting pathologies that are caused or contributed by mitochondrial dysfunction. Expand
...
1
2
3
4
5
...