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Resveratrol Prolongs Lifespan and Retards the Onset of Age-Related Markers in a Short-Lived Vertebrate
Resveratrol, a natural phytoalexin found in grapes and red wine, increases longevity in the short-lived invertebrates Caenorhabditis elegans and Drosophila and exerts a variety of biological effectsExpand
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Brain-derived neurotrophic factor promotes the differentiation of various hippocampal nonpyramidal neurons, including Cajal-Retzius cells, in organotypic slice cultures
Brain-derived neurotrophic factor (BDNF) is widely expressed in the central nervous system, where its function is poorly understood. The aim of this study was to investigate the effects of BDNF onExpand
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Annual fishes of the genus Nothobranchius as a model system for aging research
Aging research in vertebrates is hampered by the lack of short‐lived models. Annual fishes of the genus Nothobranchius live in East African seasonal ponds. Their life expectancy in the wild isExpand
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Large Differences in Aging Phenotype between Strains of the Short-Lived Annual Fish Nothobranchius furzeri
Background A laboratory inbred strain of the annual fish Nothobranchius furzeri shows exceptionally short life expectancy and accelerated expression of age markers. In this study, we analyze newExpand
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Reduced Size of Retinal Ganglion Cell Axons and Hypomyelination in Mice Lacking Brain-Derived Neurotrophic Factor
While brain-derived neurotrophic factor (BDNF) delays the death of axotomized retinal ganglion cells in rodents, it is unclear if it affects any aspect of the normal development of these cells. HereExpand
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Extremely short lifespan in the annual fish Nothobranchius furzeri
Evolutionary theories of senescence postulate that lifespan is determined by the age-dependent decrease in the effects of natural selection. Factors that influence survival and reproduction at earlyExpand
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Free Radical Scavenging and Inhibition of Nitric Oxide Synthase Potentiates the Neurotrophic Effects of Brain-Derived Neurotrophic Factor on Axotomized Retinal Ganglion Cells In Vivo
Brain-derived neurotrophic factor (BDNF) partially promotes the survival of axotomized retinal ganglion cells (RGCs). In analogy within vitro experiments (Koh et al., 1995; Samdami et al., 1996), weExpand
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Molecular determinants of retinal ganglion cell development, survival, and regeneration
The retina is an easily accessible part of the CNS with a well-defined cytological architecture. It allows for detailed study of the regulation of neurogenesis, determinants of cell fateExpand
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Brain‐derived neurotrophic factor/neurotrophin‐4 receptor TrkB is localized on ganglion cells and dopaminergic amacrine cells in the vertebrate retina
The tyrosine kinase TrkB is a receptor for the neurotrophic factors brain‐derived neurotrophic factor (BDNF) and neurotrophin‐4 (NT‐4). Retinal ganglion cells are responsive to BDNF, and TrkB hasExpand
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Effects of dietary restriction on mortality and age‐related phenotypes in the short‐lived fish Nothobranchius furzeri
The short‐lived annual fish Nothobranchius furzeri shows extremely short captive life span and accelerated expression of age markers, making it an interesting model system to investigate the effectsExpand
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