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15N NMR relaxation studies of calcium-loaded parvalbumin show tight dynamics compared to those of other EF-hand proteins.
Comparison of the Ca2+-binding EF-hand domains of alpha-parvalbumin-Ca2+, calbindin- Ca2+, and calmodulin-Ca1+ shows that parvalbumIn is probably the most rigid of the EF- hand proteins, and illustrates the dynamical properties which are conserved in theEF- hand domains from different members of this superfamily.
Structure of rat parvalbumin with deleted AB domain: Implications for the evolution of EF hand calcium‐binding proteins and possible physiological relevance
It can be concluded that the AB domain of PV protects the hydrophobic core, and is required to maintain high affinity for divalent cation binding, and possibly modulates PV buffer function.
Cytotoxic and antiparasitic activity from Annona senegalensis seeds.
Several extracts of Annona senegalensis (Annonaceae) seeds were tested for antiparasitic activity against Leishmania major, Leishmania donovani, Trypanosoma brucei brucei, and for cytotoxic activity…
Collybolide is a novel biased agonist of κ-opioid receptors with potent antipruritic activity
The discovery of a natural product from the fungus Collybia maculata as a novel scaffold that contains a furyl-δ-lactone core structure similar to that of Salvinorin A, another natural product isolated from the mint Salvia divinorum is reported, indicating a rare example of functional selectivity by two natural products that act on the same receptor.
Antiparasitic activity of Annona muricata and Annona cherimolia seeds.
The acetogenins isolated from these extracts are found to be responsible for the important activity on infective larvae of Molinema desetae.
Samvisterin, a new natural antiplasmodial betulin derivative from Uapaca paludosa (Euphorbiaceae).
Cogniauxia podolaena: bioassay-guided fractionation of defoliated stems, isolation of active compounds, antiplasmodial activity and cytotoxicity.
Both 1 and 2 have a high cytotoxicity whereas 3 shows a better selectivity index, which indicates that this plant should be considered for use in the treatment of malaria.
Aporphinoid Alkaloids. Part 4.