Skip to search formSkip to main contentSkip to account menu

15N NMR relaxation studies of calcium-loaded parvalbumin show tight dynamics compared to those of other EF-hand proteins.

TLDR
Comparison of the Ca2+-binding EF-hand domains of alpha-parvalbumin-Ca2+, calbindin- Ca2+, and calmodulin-Ca1+ shows that parvalbumIn is probably the most rigid of the EF- hand proteins, and illustrates the dynamical properties which are conserved in theEF- hand domains from different members of this superfamily.
View on PubMed (opens in a new tab)

Structure of rat parvalbumin with deleted AB domain: Implications for the evolution of EF hand calcium‐binding proteins and possible physiological relevance

TLDR
It can be concluded that the AB domain of PV protects the hydrophobic core, and is required to maintain high affinity for divalent cation binding, and possibly modulates PV buffer function.
View on Wiley (opens in a new tab)

Cytotoxic and antiparasitic activity from Annona senegalensis seeds.

Several extracts of Annona senegalensis (Annonaceae) seeds were tested for antiparasitic activity against Leishmania major, Leishmania donovani, Trypanosoma brucei brucei, and for cytotoxic activity…
View on PubMed (opens in a new tab)

Collybolide is a novel biased agonist of κ-opioid receptors with potent antipruritic activity

TLDR
The discovery of a natural product from the fungus Collybia maculata as a novel scaffold that contains a furyl-δ-lactone core structure similar to that of Salvinorin A, another natural product isolated from the mint Salvia divinorum is reported, indicating a rare example of functional selectivity by two natural products that act on the same receptor.
View on Publisher (opens in a new tab)

Antiparasitic activity of Annona muricata and Annona cherimolia seeds.

TLDR
The acetogenins isolated from these extracts are found to be responsible for the important activity on infective larvae of Molinema desetae.
View on PubMed (opens in a new tab)

Aporphine alkaloids.

View on PubMed (opens in a new tab)

Samvisterin, a new natural antiplasmodial betulin derivative from Uapaca paludosa (Euphorbiaceae).

View on PubMed (opens in a new tab)

Cogniauxia podolaena: bioassay-guided fractionation of defoliated stems, isolation of active compounds, antiplasmodial activity and cytotoxicity.

TLDR
Both 1 and 2 have a high cytotoxicity whereas 3 shows a better selectivity index, which indicates that this plant should be considered for use in the treatment of malaria.
View on PubMed (opens in a new tab)

Aporphinoid Alkaloids. Part 4.

View via Publisher (opens in a new tab)

Conformational studies on muscular parvalbumins. II. Nuclear magnetic resonance analysis.

View on PubMed (opens in a new tab)
...
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)