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Biological and chemical studies of Pera benensis, a Bolivian plant used in folk medicine as a treatment of cutaneous leishmaniasis.
The stem barks of Pera benensis are employed by the Chimane Indians in the Bolivian Amazonia as treatment of cutaneous leishmaniasis caused by the protozoan Leishmania braziliensis. The chloroformExpand
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2-substituted quinoline alkaloids as potential antileishmanial drugs.
Ten 2-substituted quinoline alkaloids isolated from a plant used for treatment of New World cutaneous leishmaniasis have antileishmanial in vitro activities against the extracellular forms ofExpand
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Altered glucose tolerance, insulin response, and insulin sensitivity after massive weight reduction subsequent to gastric bypass.
We have studied an otherwise normal group of morbidly obese subjects and compared them with patients who had experienced massive weight loss after loop gastric bypass. Compared to normal controlsExpand
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Antiprotozoal activity of quinoline alkaloids isolated from Galipea longiflora, a Bolivian plant used as a treatment for cutaneous leishmaniasis
The stem bark of Galipea longiflora is used by the Chimane Indians in Bolivia for the treatment of cutaneous leishmaniasis produced by Leishmania braziliensis. Petroleum ether and chloroform extractsExpand
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Cytotoxic and antiparasitic activity from Annona senegalensis seeds.
Several extracts of Annona senegalensis (Annonaceae) seeds were tested for antiparasitic activity against Leishmania major, Leishmania donovani, Trypanosoma brucei brucei, and for cytotoxic activityExpand
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15N NMR relaxation studies of calcium-loaded parvalbumin show tight dynamics compared to those of other EF-hand proteins.
Dynamics of the rat alpha-parvalbumin calcium-loaded form have been determined by measurement of 15N nuclear relaxation using proton-detected heteronuclear NMR spectroscopy. The relaxation data wereExpand
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Structure of rat parvalbumin with deleted AB domain: Implications for the evolution of EF hand calcium‐binding proteins and possible physiological relevance
Among the EF‐hand Ca2+‐binding proteins, parvalbumin (PV) and calbindin D9k (CaB) have the function of Ca2+ buffers. They evolved from an ancestor protein through two phylogenetic pathways, keepingExpand
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Collybolide is a novel biased agonist of κ-opioid receptors with potent antipruritic activity
Significance In recent years, the κ-opioid receptor (κOR) has become an attractive therapeutic target for the treatment of a number of disorders including depression, visceral pain, and drugExpand
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Antiprotozoal activity of aporphine alkaloids isolated from Unonopsis buchtienii (Annonaceae)
On a preliminary screening, substantial leishmanicidal activity was observed for the petroleum ether and alkaloidal extracts of the stem bark of Unonopsis buchtienii, the alkaloids and sterolsExpand
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Antiparasitic activity of Annona muricata and Annona cherimolia seeds.
Methanolic extracts of Annona muricata and A. cherimolia (Annonaceae) seeds were tested for antiparasitic activity against E. histolytica, N. brasiliensis, M. dessetae and A. salina. The acetogeninsExpand
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