• Publications
  • Influence
Neutral endopeptidase inhibition and the natriuretic peptide system: an evolving strategy in cardiovascular therapeutics.
TLDR
The current knowledge of the use and effects of NEPinh alone or in combination with other therapeutic agents for the treatment of human cardiovascular disease such as HF and hypertension is summarized.
Left ventricular mass monitoring in the follow-up of dialysis patients: prognostic value of left ventricular hypertrophy progression.
TLDR
Changes in LVMI have an independent prognostic value for cardiovascular events and provide scientific support to the use of repeated echocardiographic studies for monitoring cardiovascular risk in dialysis patients.
Quantitative mass spectral evidence for the absence of circulating brain natriuretic peptide (BNP-32) in severe human heart failure.
TLDR
An immunoaffinity purification assay is developed and used to isolate endogenous BNP-32 from New York Heart Association class IV patient plasma for subsequent analysis by nano-liquid chromatography (LC) electrospray ionization Fourier transform ion cyclotron resonance (FT-ICR) MS.
Brain Natriuretic Peptide Is Produced in Cardiac Fibroblasts and Induces Matrix Metalloproteinases
TLDR
In vitro findings support a role for BNP as a regulator of myocardial structure via control of cardiac fibroblast function and that BNP decreases collagen synthesis and increases MMPs via cGMP–protein kinase G signaling.
Prognostic value of echocardiographic indicators of left ventricular systolic function in asymptomatic dialysis patients.
TLDR
The study of myocardial contractility by echocardiography provides prognostic information independently of LV mass and other risk factors in ESRD, and risk stratification by simple systolic function parameters may prove useful in secondary prevention strategies in patients.
Hyperhomocysteinemia predicts cardiovascular outcomes in hemodialysis patients.
TLDR
There is a clear association between hyperhomocysteinemia and incident cardiovascular mortality and atherothrombotic events in hemodialysis patients and intervention studies are needed to determine whether the accumulation of this substance has a causal role in the pathogenesis of cardiovascular damage in patients undergoing hemodIALysis.
Circulating natriuretic peptide concentrations in patients with end-stage renal disease: role of brain natriuretic peptide as a biomarker for ventricular remodeling.
TLDR
Elevation of the plasma BNP concentration is more specifically related to LVH compared with the other NP levels in patients with ESRD independent of congestive heart failure, and serves as an important plasma biomarker for ventricular hypertrophy in dialysis patients withESRD.
Targeting Heme-Oxidized Soluble Guanylate Cyclase in Experimental Heart Failure
TLDR
Beneficial properties make direct soluble guanylate cyclase stimulation with BAY 58-2667 a promising new therapeutic strategy for cardiovascular diseases, such as heart failure.
...
...