Author pages are created from data sourced from our academic publisher partnerships and public sources.
Share This Author
A long noncoding RNA associated with susceptibility to celiac disease
Lnc13 levels are significantly decreased in small intestinal biopsy samples from patients with celiac disease, which suggests that down-regulation of lnc13 may contribute to the inflammation seen in this disease.
TH17 (and TH1) signatures of intestinal biopsies of CD patients in response to gliadin
- A. Castellanos-Rubio, I. Santin, I. Irastorza, L. Castaño, Juan Carlos Vitoria, J. Ramon Bilbao
- Medicine, BiologyAutoimmunity
- 1 January 2009
CD is placed into the group of autoimmune disorders in which TH17 cells also participate, although the relative importance of each T cell response and their role in the initial events of the disease need further investigation.
Revisiting genome wide association studies (GWAS) in coeliac disease: replication study in Spanish population and expression analysis of candidate genes
- Leticia Plaza-Izurieta, A. Castellanos-Rubio, I. Irastorza, N. Fernandez-Jimenez, G. Gutiérrez, J. Bilbao
- Biology, MedicineJournal of Medical Genetics
- 13 April 2011
Exchange differences between treated CD patients and controls along with SNP expression associations suggest a possible primary role for these four genes and their variants in pathogenesis.
Coregulation and modulation of NFκB-related genes in celiac disease: uncovered aspects of gut mucosal inflammation
- N. Fernandez-Jimenez, A. Castellanos-Rubio, J. Bilbao
- BiologyHuman molecular genetics
- 24 October 2013
The results confirm the upregulation of the NFκB pathway and show that constitutively altered genes usually belong to the core of the pathway and have central roles, whereas genes overexpressed only in active CD are more peripheral.
Disease-Associated SNPs in Inflammation-Related lncRNAs
High-throughput genomic studies performed in the past few years have revealed that many of the non-coding regions bearing disease-associated SNPs generate long non-Coding RNAs (lncRNAs), which have been implicated in several inflammatory diseases, and many of them have been shown to function as regulators of gene expression.
Accuracy in Copy Number Calling by qPCR and PRT: A Matter of DNA
Analysis of three genes in a large sample set showed that both quantitative PCR and paralog ratio test are prone to false copy number assignments if sufficient attention is not paid to DNA concentration and quality.
Cytoplasmic Form of Carlr lncRNA Facilitates Inflammatory Gene Expression upon NF-κB Activation
It is suggested that increased Carlr expression and/or cytoplasmic localization is required for efficient NF-κB signaling and is associated with the inflamed tissue state observed in human celiac disease.
Toll-like receptor 4 (TLR4) gene polymorphisms in celiac disease.
- I. Santin, A. Castellanos-Rubio, I. Hualde, L. Castaño, J. C. Vitoria, J. Bilbao
- Biology, MedicineTissue antigens
- 1 December 2007
The results do not support association of these coding single nucleotide polymorphisms of TLR4 variants with CD.
The functional R620W variant of the PTPN22 gene is associated with celiac disease.
- I. Santin, A. Castellanos-Rubio, A. Aransay, L. Castaño, J. C. Vitoria, J. Bilbao
- Medicine, BiologyTissue antigens
- 1 March 2008
The role of PTPN22 as a general autoimmunity locus involved in tolerance induction in the thymus is supported, and an association study with celiac disease showed a higher frequency of the minor allele in the CD group.
The T1D-associated lncRNA Lnc13 modulates human pancreatic β cell inflammation by allele-specific stabilization of STAT1 mRNA
- I. Gonzalez-Moro, A. Olazagoitia-Garmendia, I. Santin
- BiologyProceedings of the National Academy of Sciences
- 13 April 2020
A complete functional characterization of a lncRNA that harbors a single nucleotide polymorphism (SNP) associated with T1D, namely, Lnc13 is performed and it is observed that PIC, a viral mimetic, induces L NC13 translocation from the nucleus to the cytoplasm promoting the interaction of STAT1 mRNA with (poly[rC] binding protein 2) (PCBP2).