Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene.
- A. Caspi, K. Sugden, R. Poulton
- Psychology, BiologyScience
- 2003
Evidence of a gene-by-environment interaction is provided, in which an individual's response to environmental insults is moderated by his or her genetic makeup.
Role of Genotype in the Cycle of Violence in Maltreated Children
- A. Caspi, J. McClay, R. Poulton
- Psychology, BiologyScience
- 13 June 2002
A functional polymorphism in the gene encoding the neurotransmitter-metabolizing enzyme monoamine oxidase A was found to moderate the effect of maltreatment, and it was found that Maltreated children with a genotype conferring high levels of MAOA expression were less likely to develop antisocial problems.
A gradient of childhood self-control predicts health, wealth, and public safety
- T. Moffitt, L. Arseneault, A. Caspi
- PsychologyProceedings of the National Academy of Sciences
- 24 January 2011
Following a cohort of 1,000 children from birth to the age of 32 y, it is shown that childhood self-control predicts physical health, substance dependence, personal finances, and criminal offending outcomes, following a gradient of self- control.
Influence of Life Stress on Depression: Moderation by a Polymorphism in the 5-HTT Gene
- A. Caspi, K. Sugden, R. Poulton
- Psychology, BiologyScience
- 18 July 2003
Evidence of a gene-by-environment interaction is provided, in which an individual's response to environmental insults is moderated by his or her genetic makeup.
Personality development: stability and change.
- A. Caspi, B. Roberts, R. Shiner
- PsychologyAnnual Review of Psychology
- 11 March 2005
This review examines research about the structure of personality in childhood and in adulthood, with special attention to possible developmental changes in the lower-order components of broad traits.
Males on the life-course-persistent and adolescence-limited antisocial pathways: Follow-up at age 26 years
- T. Moffitt, A. Caspi, H. Harrington, B. Milne
- PsychologyDevelopment and Psychopathology
- 1 March 2002
Findings support the theory of life-course-persistent and adolescence-limited antisocial behavior but also extend it, and recommend intervention with all aggressive children and with all delinquent adolescents, to prevent a variety of maladjustments in adult life.
Sex Differences in Antisocial Behaviour Conduct Disorder, Delinquency, and Violence in the Dunedin Longitudinal Study
- T. Moffitt, A. Caspi, M. Rutter, Phil A. Silva
- Psychology, BiologyDECP Debate
- 27 September 2001
The recommendation to relax the criteria for diagnosing conduct disorder in girls and the effects of antisocial behaviour on young adult outcomes is evaluated.
Female and male antisocial trajectories: From childhood origins to adult outcomes
- C. Odgers, T. Moffitt, A. Caspi
- PsychologyDevelopment and Psychopathology
- 1 March 2008
Findings support similarities across gender with respect to developmental trajectories of antisocial behavior and their associated childhood origins and adult consequences.
Genetic Sensitivity to the Environment: The Case of the Serotonin Transporter Gene and Its Implications for Studying Complex Diseases and Traits
- A. Caspi, A. Hariri, A. Holmes, R. Uher, T. Moffitt
- Biology
- 1 July 2010
The authors evaluate four lines of evidence about the 5-HTT stress-sensitivity hypothesis: observational studies about the serotonin transporter linked polymorphic region (5-HTTLPR), stress sensitivity, and depression in humans, research about one of the most extensive areas of inquiry.
Prior juvenile diagnoses in adults with mental disorder: developmental follow-back of a prospective-longitudinal cohort.
- J. Kim-Cohen, A. Caspi, T. Moffitt, H. Harrington, B. Milne, R. Poulton
- Medicine, PsychologyArchives of General Psychiatry
- 1 July 2003
Most adult disorders should be reframed as extensions of juvenile disorders, in particular, juvenile conduct disorder is a priority prevention target for reducing psychiatric disorder in the adult population.
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