• Publications
  • Influence
Misconduct accounts for the majority of retracted scientific publications
TLDR
A detailed review of all 2,047 biomedical and life-science research articles indexed by PubMed as retracted on May 3, 2012 revealed that only 21.3% of retractions were attributable to error, compared with 67.4% attributable to misconduct, including fraud or suspected fraud, duplicate publication, and plagiarism. Expand
Fungal Cell Gigantism during Mammalian Infection
TLDR
A remarkable new strategy for C. neoformans to evade the immune response by enlarging cell size is described, and it is suggested that gigantism results from replication without fission, a phenomenon that may also occur with other fungal pathogens. Expand
Through the wall: extracellular vesicles in Gram-positive bacteria, mycobacteria and fungi
TLDR
The current status of vesiculogenesis research in thick-walled microorganisms is described and the cargo and functions associated with EVs in these species are discussed. Expand
Phagosome Extrusion and Host-Cell Survival after Cryptococcus neoformans Phagocytosis by Macrophages
TLDR
The phenomenon of "phagosomal extrusion" indicates the existence of a previously unrecognized mechanism whereby a fungal pathogen can escape the intracellular confines of mammalian macrophages to continue propagation and, possibly, dissemination. Expand
Cryptococcus neoformans interactions with amoebae suggest an explanation for its virulence and intracellular pathogenic strategy in macrophages
TLDR
The results suggest that the virulence of Cn for mammalian cells is a consequence of adaptations that have evolved for protection against environmental predators such as amoebae and provide an explanation for the broad host range of this pathogenic fungus. Expand
Bacillus anthracis produces membrane-derived vesicles containing biologically active toxins
TLDR
The results indicate that toxin secretion in B. anthracis is, at least, partially vesicle-associated, thus allowing concentrated delivery of toxin components to target host cells, a mechanism that may increase toxin potency. Expand
Host-Pathogen Interactions: Redefining the Basic Concepts of Virulence and Pathogenicity
TLDR
Historical concepts of microbial pathogenicity and virulence are reviewed, new definitions are proposed, and a classification system for microbial pathogens based on their ability to cause damage as a function of the host’s immune response is suggested. Expand
Synthesis and assembly of fungal melanin
TLDR
Recent studies suggest the fungal melanin may be synthesized in internal vesicles akin to mammalian melanosomes and transported to the cell wall and take advantage of melanin's radioprotective properties and propensity to bind to a variety of substances. Expand
Extracellular Vesicles Produced by Cryptococcus neoformans Contain Protein Components Associated with Virulence
TLDR
An efficient and general mechanism of secretion of pathogenesis-related molecules in C. neoformans is revealed, suggesting that extracellular vesicles function as “virulence bags” that deliver a concentrated payload of fungal products to host effector cells and tissues. Expand
...
1
2
3
4
5
...