• Publications
  • Influence
Supply and Demand in Cerebral Energy Metabolism: The Role of Nutrient Transporters
Simulations based on concentrations and kinetic parameters of GLUT1 and −3 in BBB endothelial cells, astrocytes, and neurons, along with the corresponding kinetic properties of the MCTs, have successfully modeled brain glucose and lactate levels as well as lactate transients in response to neuronal stimulation. Expand
Facilitated diffusion of glucose.
  • A. Carruthers
  • Chemistry, Medicine
  • Physiological reviews
  • 1 October 1990
Article de synthese sur the diffusion facilite du glucose a travers les membranes cellulaires a travers le membranes cellulaire. Expand
Will the original glucose transporter isoform please stand up!
This review addresses protein-mediated, equilibrative glucose transport catalyzed by GLUT1, the first equilbrative glucose transporter to be identified, purified, and cloned, and concludes that no single model satisfactorily explainsGLUT1 behavior. Expand
The in vivo neuron‐to‐astrocyte lactate shuttle in human brain: evidence from modeling of measured lactate levels during visual stimulation
The mathematical model introduced by Simpson et al. (2007) is utilized to gain insights into compartmentalized metabolism in vivo from the fMRS data obtained in humans at ultra high magnetic field, and results indicate that the results are consistent with export of lactate by neurons and import of lactates by astrocytes. Expand
Glucose transporter oligomeric structure determines transporter function. Reversible redox-dependent interconversions of tetrameric and dimeric GLUT1.
It is proposed that native structure is established prior to transporter translocation to the plasma membrane and that intrasubunit disulfide bonds promote cooperative subunit interactions that stabilize transporter structure and function. Expand
A Novel Model for Brain Iron Uptake: Introducing the Concept of Regulation
An in vivo model of brain iron deficiency, the Belgrade rat, is used and the presence of factors that influence iron release in non-human primate cerebrospinal fluid and conditioned media from astrocytes are integrated into an interactive model where BBB ECs are central in the regulation of cerebral iron metabolism. Expand
Human erythrocyte sugar transport is incompatible with available carrier models.
It is suggested that GLUT1-mediated sugar transport in all cells is an intrinsically symmetric process but that intracellular sugar complexation in human red cells prevents accurate determination of transport rates. Expand
Glucose transporter function is controlled by transporter oligomeric structure. A single, intramolecular disulfide promotes GLUT1 tetramerization.
It is concluded that each subunit of the glucose transporter contains an extracellular disulfide bridge that stabilizes transporter oligomeric structure and thereby accelerates transport function. Expand
Equilibrium ligand binding to the human erythrocyte sugar transporter. Evidence for two sugar-binding sites per carrier.
The experimental results are inconsistent with the one- site model but are explained by a two-site model in which the ternary complexes of So . Expand
Response to ‘Comment on Recent Modeling Studies of Astrocyte—Neuron Metabolic Interactions’: Much ado about Nothing
Although simulations continue to support the predominance of neuronal glucose utilization during activation and neuronal to astrocytic lactate flow, the most important result is that the overall contribution of lactate to cerebral glucose metabolism is found to be so small as to make this ongoing debate ‘much ado about nothing'. Expand