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Plasma Membrane Ca2+ Pump in Rat Brain
TLDR
The distinct patterns of expression of the PMCA isoforms in brain suggest that some of them play a special role in intracellular Ca regulation.
The Plasma Membrane Calcium Pump Displays Memory of Past Calcium Spikes
TLDR
The memory effect observed in PMCA2b and 4b will allow cells expressing either of them to remove Ca2+ more quickly in subsequent spikes after an initial activating spike, and is due to calmodulin remaining bound to the enzyme during the period at low Ca2+.
Delayed activation of the plasma membrane calcium pump by a sudden increase in Ca2+: fast pumps reside in fast cells.
TLDR
It is found that different PMCAs are activated by Ca(2+) at different rates, PMCA 3f and 2a being the fastest, and 4b the slowest, and the results suggest that the type of PMCA expressed will correspond with the speed of Ca( 2+) signals in the cell.
Plasma-membrane Ca(2+) pumps: structural diversity as the basis for functional versatility.
TLDR
Structural diversity provides functional versatility in the PMCAs, with specific pumps being essential for cochlear hair cell function, sperm motility, feedback signalling in the heart and pre- and post-synaptic Ca(2+) regulation in neurons.
Plasma membrane calcium pump and 28-kDa calcium binding protein in cells of rat kidney distal tubules.
TLDR
It is shown that Ca2+-Mg2-ATPase and 28-kDa CaBP are present in the principal cells of the distal convoluted tubule of the rat and are absent in intercalated cells.
Modification of human hearing loss by plasma-membrane calcium pump PMCA2.
TLDR
A heterozygous, hypofunctional variant (V586M) in plasma-membrane calcium pump PMCA2, which is encoded by ATP2B2, was associated with increased loss in the three severely affected siblings.
Detection of isoform 4 of the plasma membrane calcium pump in human tissues by using isoform-specific monoclonal antibodies.
TLDR
The distribution of the a and b forms of hPMCA4 at the protein level, as analysed by these antibodies, is consistent with the available data about the abundance of mRNAs for the h PMCA isoforms.
Plasma Membrane Ca2+ ATPases as Dynamic Regulators of Cellular Calcium Handling
TLDR
Plasma membrane Ca2+ ATPases (PMCAs) are essential components of the cellular toolkit to regulate and fine‐tune cytosolic Ca 2+ concentrations and the regulated deployment and retrieval of PMCAs from specific membranes provide a dynamic system for a cell to respond to changing needs of Ca2+.
A Potent and Specific CD38 Inhibitor Ameliorates Age-Related Metabolic Dysfunction by Reversing Tissue NAD+ Decline.
TLDR
It is shown that a highly potent and specific thiazoloquin(az)olin(on)e CD38 inhibitor, 78c, reverses age-related NAD+ decline and improves several physiological and metabolic parameters of aging, including glucose tolerance, muscle function, exercise capacity, and cardiac function in mouse models of natural and accelerated aging.
Calcium pump epitopes in placental trophoblast basal plasma membranes.
TLDR
It is concluded that basal (fetal facing) layers of human and rat placentas contain a high-affinity Ca2+ pump situated to transportCa2+ from the maternal to the fetal circulation.
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