Endogenous kappa-opioid mediation of stress-induced potentiation of ethanol-conditioned place preference and self-administration
- R. Sperling, Stacey M. Gomes, Elizabeth I Sypek, A. Carey, J. McLaughlin
- Biology, PsychologyPsychopharmacology
- 17 April 2010
These data demonstrated a stress-induced potentiation of the rewarding effects and self-administration of ethanol mediated by KOR signaling, as well as demonstrating the role of the KOR in the resulting behaviors.
Anthocyanin-rich açai (Euterpe oleracea Mart.) fruit pulp fractions attenuate inflammatory stress signaling in mouse brain BV-2 microglial cells.
- S. Poulose, D. Fisher, B. Shukitt-Hale
- BiologyJournal of Agricultural and Food Chemistry
- 20 January 2012
The protection of microglial cells by açai pulp extracts was also accompanied by a significant concentration-dependent reduction in cyclooxygenase-2, p38 mitogen-activated protein kinase (p38-MAPK), tumor necrosis factor-α (TNFα), and nuclear factor κB (NF-κB).
Expression of HIV-Tat protein is associated with learning and memory deficits in the mouse
Modulation of oxidative stress, inflammation, autophagy and expression of Nrf2 in hippocampus and frontal cortex of rats fed with açaí-enriched diets
- S. Poulose, D. Bielinski, A. Carey, A. Schauss, B. Shukitt-Hale
- BiologyNutritional neuroscience
- 28 May 2017
An açaí-enriched diet could possibly modulate Nrf2, which is known to modulate the intracellular redox status, thereby regulating the ubiquitin-proteosomal pathway, ultimately affecting cognitive function in the aging brain.
Effects of Concord grape juice on cognitive and motor deficits in aging.
Blueberry polyphenols attenuate kainic acid-induced decrements in cognition and alter inflammatory gene expression in rat hippocampus
Results indicate that blueberry polyphenols attenuate learning impairments following neurotoxic insult and exert anti-inflammatory actions, perhaps via alteration of gene expression.
Beneficial effects of fruit extracts on neuronal function and behavior in a rodent model of accelerated aging
Reinstatement of cocaine place-conditioning prevented by the peptide kappa-opioid receptor antagonist arodyn.
Endogenous κ Opioid Activation Mediates Stress-Induced Deficits in Learning and Memory
- A. Carey, Angela M Lyons, Christopher F. Shay, Ocean Dunton, J. McLaughlin
- Biology, PsychologyJournal of Neuroscience
- 1 April 2009
Results suggest that stress-induced activation of the KOR may be both necessary and sufficient to produce subsequent deficits in novel object recognition.
Effects of Conditional Central Expression of HIV-1 Tat Protein to Potentiate Cocaine-Mediated Psychostimulation and Reward Among Male Mice
- J. Paris, A. Carey, Christopher F. Shay, Stacey M. Gomes, Johnny J. He, J. McLaughlin
- Biology, PsychologyNeuropsychopharmacology
Together, these data suggest that central HIV-1 Tat expression can potentiate the psychostimulant behavioral effects of cocaine in mice.