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Dihydroceramide delays cell cycle G1/S transition via activation of ER stress and induction of autophagy.
Dihydroceramides, the precursors of ceramides in the de novo sphingolipid synthesis, have been recently implicated in active signalling. We previously demonstrated that dihydroceramide accumulation,Expand
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Role of Sphingolipids in the Pathobiology of Lung Inflammation
Sphingolipid bioactivities in the respiratory airways and the roles of the proteins that handle them have been extensively investigated. Gas or inhaled particles or microorganisms come into contactExpand
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DNA methylation and histone modifications modulate the β1,3 galactosyltransferase β3Gal-T5 native promoter in cancer cells.
The native promoter of β1,3 galactosyltransferase β3Gal-T5 contributes to the expression of the enzyme and its oligosaccharide products, such as Lewis antigens, in many tissues. It is mainlyExpand
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Chronic systemic hypoxia promotes LNCaP prostate cancer growth in vivo
Solid tumors contain underperfused regions where hypoxia‐inducible factor‐1α (HIF‐1α) over‐expression induces hypoxia adaptation and cell proliferation. We test the hypothesis that systemic hypoxiaExpand
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Myriocin treatment of CF lung infection and inflammation: complex analyses for enigmatic lipids
Our aim was to use quantitative and qualitative analyses to gain further insight into the role of ceramide in cystic fibrosis (CF). Sphingolipid ceramide is a known inflammatory mediator, and itsExpand
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Supplementation of creatine and ribose prevents apoptosis and right ventricle hypertrophy in hypoxic hearts.
BACKGROUND/AIMS The simultaneous supplementation of creatine and D-ribose has been shown to reduce apoptosis in vitro in non-irreversibly injured cultured ischemic cardiomyocytes throughExpand
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Carbamylated erythropoietin ameliorates the metabolic stress induced in vivo by severe chronic hypoxia
Ischemia and chronic hypoxia (CH) trigger a variety of adverse effects arising from metabolic stress that injures cells. In response to reduced O2, hypoxia-inducible factor 1α (HIF-1α) activatesExpand
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The biosynthesis of the selectin-ligand sialyl Lewis x in colorectal cancer tissues is regulated by fucosyltransferase VI and can be inhibited by an RNA interference-based approach.
Sialyl Lewis x (sLex) is a selectin ligand whose overexpression in epithelial cancers mediates metastasis formation. The molecular basis of sLex biosynthesis in colon cancer tissues is still unclear.Expand
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Phosphodiesterase-5 Inhibition Abolishes Neuron Apoptosis Induced by Chronic Hypoxia Independently of Hypoxia-Inducible Factor-1α Signaling
Exposure to hypoxia triggers a variety of adverse effects in the brain that arise from metabolic stress and induce neuron apoptosis. Overexpression of the hypoxia-inducible factor-1α (HIF-1α) isExpand
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Inhibition of ceramide de novo synthesis as a postischemic strategy to reduce myocardial reperfusion injury
The injury caused by myocardial reperfusion after ischemia can be contained by interventions aimed at reducing the inflammation and the oxidative stress that underlie exacerbation of tissue damage.Expand
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