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Range uncertainty in proton therapy due to variable biological effectiveness.
Traditionally, dose in proton radiotherapy is prescribed as Gy(RBE) by scaling up the physical dose by 10%. The relative biological effectiveness (RBE) of protons is considered to vary withExpand
A critical study of different Monte Carlo scoring methods of dose average linear-energy-transfer maps calculated in voxelized geometries irradiated with clinical proton beams.
We compare unrestricted dose average linear energy transfer (LET) maps calculated with three different Monte Carlo scoring methods in voxelized geometries irradiated with proton therapy beams withExpand
Clinical consequences of relative biological effectiveness variations in proton radiotherapy of the prostate, brain and liver.
Proton relative biological effectiveness (RBE) is known to depend on the (α/β)x of irradiated tissues, with evidence of ∼60% variation over (α/β)x values from 1-10 Gy. The range of (α/β)x valuesExpand
Analytical calculation of proton linear energy transfer in voxelized geometries including secondary protons.
In order to integrate radiobiological modelling with clinical treatment planning for proton radiotherapy, we extended our in-house treatment planning system FoCa with a 3D analytical algorithm toExpand
Linear energy transfer painting with proton therapy: a means of reducing radiation doses with equivalent clinical effectiveness.
PURPOSE The purpose of this study was to propose a proton treatment planning method that trades physical dose (D) for dose-averaged linear energy transfer (LETd) while keeping the radiobiologicallyExpand
Optical super-resolution imaging by high-index microspheres embedded in elastomers.
We demonstrated feasibility of super-resolution imaging through high-index microspheres embedded in transparent elastomers. We performed imaging, with resolution improvement by a factor of two, byExpand
Range optimization for mono- and bi-energetic proton modulated arc therapy with pencil beam scanning.
The development of rotational proton therapy plans based on a pencil-beam-scanning (PBS) system has been limited, among several other factors, by the energy-switching time between layers, aExpand
FoCa: a modular treatment planning system for proton radiotherapy with research and educational purposes.
FoCa is an in-house modular treatment planning system, developed entirely in MATLAB, which includes forward dose calculation of proton radiotherapy plans in both active and passive modalities as well as a generic optimization suite for inverse treatment planning. Expand
Silicon-based three-dimensional microstructures for radiation dosimetry in hadrontherapy
In this work, we propose a solid-state-detector for use in radiation microdosimetry. This device improves the performance of existing dosimeters using customized 3D-cylindrical microstructures etchedExpand
Dose-averaged LET calculation for proton track segments using microdosimetric Monte Carlo simulations.
PURPOSE There is an increasing interest in calculating LET distributions for proton therapy treatments in order to assess the influence of this quantity in biological terms. Microdosimetric MonteExpand