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In vitro chondrogenesis of bone marrow-derived mesenchymal progenitor cells.
A culture system that facilitates the chondrogenic differentiation of rabbit bone marrow-derived mesenchymal progenitor cells has been developed. Cells obtained in bone marrow aspirates were firstExpand
Osteogenic differentiation of purified, culture‐expanded human mesenchymal stem cells in vitro
The formation of a continuously interconnected network of APase‐positive cells and mineralized matrix supports the characterization of this progenitor population as homogeneous, and suggests a role for autocrine or paracrine factors synthesized by human MSCs undergoing osteoblastic lineage progression. Expand
Mesenchymal stem cells as trophic mediators
Several studies which tested the use of MSCs in models of infarct (injured heart), stroke (brain), or meniscus regeneration models are reviewed within the context of M SC‐mediated trophic effects in tissue repair. Expand
A New Human Somatic Stem Cell from Placental Cord Blood with Intrinsic Pluripotent Differentiation Potential
A new, intrinsically pluripotent, CD45-negative population from human cord blood, termed unrestricted somatic stem cells (USSCs) is described, which grows adherently and can be expanded to 1015 cells without losing pluripotency. Expand
Adult mesenchymal stem cells for tissue engineering versus regenerative medicine
  • A. Caplan
  • Biology, Medicine
  • Journal of cellular physiology
  • 1 November 2007
The biological basis for the in vivo functioning of MSCs through development and aging is summarized and they appear to be valuable mediators for tissue repair and regeneration. Expand
Mechanisms involved in the therapeutic properties of mesenchymal stem cells.
Some of the molecules involved in the paracrine effects of MSCs are identified with a perspective that these cells intrinsically belong to a perivascular niche in vivo, and how this knowledge could be advantageously used in clinical applications is discussed. Expand
Sulfated proteoglycans in astroglial barriers inhibit neurite outgrowth in vitro
It is demonstrated that KS/CS-PG is inhibitory to embryonic dorsal root ganglia neurites in vitro and that complete inhibition requires contributions from both KS and CS moieties. Expand
In Search of the In Vivo Identity of Mesenchymal Stem Cells
This model proposes that MSCs stabilize blood vessels and contribute to tissue and immune system homeostasis under physiological conditions and assume a more active role in the repair of focal tissue injury and provides a basis for the rational design of additional in vivo therapeutic approaches. Expand
Mesenchymal cell-based repair of large, full-thickness defects of articular cartilage.
As demonstrated in this report, autologous, bone-marrow-derived, osteochondral progenitor cells can be isolated and grown in vitro without the loss of their capacity to differentiate into cartilage or bone. Expand
Rapid hematopoietic recovery after coinfusion of autologous-blood stem cells and culture-expanded marrow mesenchymal stem cells in advanced breast cancer patients receiving high-dose chemotherapy.
It is found that autologous MSC infusion at the time of PBPC transplantation is feasible and safe, and the observed rapid hematopoietic recovery suggests that M SC infusion after myeloablative therapy may have a positive impact on hematoiesis and should be tested in randomized trials. Expand