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A Myc Network Accounts for Similarities between Embryonic Stem and Cancer Cell Transcription Programs
c-Myc (Myc) is an important transcriptional regulator in embryonic stem (ES) cells, somatic cell reprogramming, and cancer. Here, we identify a Myc-centered regulatory network in ES cells byExpand
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Human Fetal Hemoglobin Expression Is Regulated by the Developmental Stage-Specific Repressor BCL11A
Differences in the amount of fetal hemoglobin (HbF) that persists into adulthood affect the severity of sickle cell disease and the β-thalassemia syndromes. Genetic association studies haveExpand
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Association between high levels of expression of the TRK gene and favorable outcome in human neuroblastoma.
BACKGROUND AND METHODS The nerve growth factor receptor is expressed in some neuroblastomas, in which its primary component is encoded by the TRK protooncogene. To determine the relation of theExpand
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Targeted Deletion of a High-Affinity GATA-binding Site in the GATA-1 Promoter Leads to Selective Loss of the Eosinophil Lineage In Vivo
Transcription factor GATA-1 reprograms immature myeloid cells to three different hematopoietic lineages-erythroid cells, megakaryocytes, and eosinophils. GATA-1 is essential for maturation ofExpand
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Insights into GATA-1-mediated gene activation versus repression via genome-wide chromatin occupancy analysis.
The transcription factor GATA-1 is required for terminal erythroid maturation and functions as an activator or repressor depending on gene context. Yet its in vivo site selectivity and ability toExpand
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Sample-size calculations for Cohen's kappa.
In recent years, researchers in the psychosocial and biomedical sciences have become increasingly aware of the importance of sample-size calculations in the design of research projects. SuchExpand
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FOG-2: A novel GATA-family cofactor related to multitype zinc-finger proteins Friend of GATA-1 and U-shaped.
GATA factors are transcriptional regulatory proteins that play critical roles in the differentiation of multiple cell types in both vertebrates and invertebrates. Recent evidence suggests that theExpand
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Transcriptional regulation of erythropoiesis: an affair involving multiple partners
Previous work has demonstrated that lineage-specific transcription factors play essential roles in red blood cell development. More recent studies have shown that these factors participate inExpand
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BRCA1 and BRCA2 mutations account for a large proportion of ovarian carcinoma cases
It is believed that BRCA1 and BRCA2 germline mutations account for the majority of hereditary ovarian carcinomas; however, to the authors' knowledge, there are scant data on the prevalence andExpand
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Tumor Biology of Infiltrating Lobular Carcinoma: Implications for Management
Objective The purpose of this study was to characterize the biologic determinants that affect the behavior and management of infiltrating lobular cancer. Methods A prospectively accrued data baseExpand
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