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Human Fetal Hemoglobin Expression Is Regulated by the Developmental Stage-Specific Repressor BCL11A
TLDR
BCL11A emerges as a therapeutic target for reactivation of HbF in β-hemoglobin disorders and occupies several discrete sites in the β-globin gene cluster, consistent with a direct role of BCL 11A in globin gene regulation. Expand
A Myc Network Accounts for Similarities between Embryonic Stem and Cancer Cell Transcription Programs
TLDR
A Myc-centered regulatory network in ES cells is identified by combining protein-protein and protein-DNA interaction studies and it is shown that Myc interacts with the NuA4 complex, a regulator of ES cell identity. Expand
Discovery of JSI-124 (cucurbitacin I), a selective Janus kinase/signal transducer and activator of transcription 3 signaling pathway inhibitor with potent antitumor activity against human and murine
TLDR
The suppression of phosphotyrosine STAT3 levels resulted in the inhibition of STAT3 DNA binding and STAT3-mediated but not serum response element-mediated gene transcription, giving strong support for pharmacologically targeting the JAK/STAT3 signaling pathway for anticancer drug discovery. Expand
Lymphatic mapping and sentinel node biopsy in the patient with breast cancer.
TLDR
This study confirms that lymphatic mapping is technically possible in the patient with breast cancer and that the Histologic characteristics of the SLN probably reflect the histologic characteristicsof the rest of the axillary lymph nodes. Expand
Association between high levels of expression of the TRK gene and favorable outcome in human neuroblastoma.
TLDR
A tumor with a functional nerve growthFactor receptor may be dependent on the neurotrophin nerve growth factor for survival and may regress in its absence, allowing a new approach to the treatment of certain patients with neuroblastoma. Expand
Targeted Deletion of a High-Affinity GATA-binding Site in the GATA-1 Promoter Leads to Selective Loss of the Eosinophil Lineage In Vivo
TLDR
Findings suggest that GATA-1 is required for specification of this lineage during hematopoietic development, and mice lacking the ability to produce eosinophils should prove useful in ascertaining the role of eosInophils in a variety of inflammatory or allergic disorders. Expand
Insights into GATA-1-mediated gene activation versus repression via genome-wide chromatin occupancy analysis.
TLDR
It is shown that the transcription factor Zbtb7a occupies GATA-1-bound regions of some direct Gata-1 target genes, that the presence of SCL/TAL1 helps distinguish transcriptional activation versus repression, and that polycomb repressive complex 2 (PRC2) is involved in epigenetic silencing of a subset of GATA -1-repressed genes. Expand
Constitutive activation of Stat3 in human prostate tumors and cell lines: direct inhibition of Stat3 signaling induces apoptosis of prostate cancer cells.
TLDR
It is demonstrated that constitutive activation of Stat3 occurs frequently in primary prostate adenocarcinomas and is critical for the growth and survival of prostate cancer cells. Expand
Activation of Stat3 in Primary Tumors from High-Risk Breast Cancer Patients Is Associated with Elevated Levels of Activated Src and Survivin Expression
TLDR
These findings suggest that specific Stat3 or Src inhibitors could offer clinical benefits to patients with breast cancer and suggest important roles for elevated activities of Stat3 and Src, as well as Survivin expression, in malignant progression of breast cancer. Expand
FOG-2: A novel GATA-family cofactor related to multitype zinc-finger proteins Friend of GATA-1 and U-shaped.
TLDR
Members of the FOG family of cofactors share highly specific association with GATA factors and are substantially interchangeable with respect to some aspects of function in vivo, constituting an evolutionarily conserved paradigm for transcriptional control in differentiation and organogenesis. Expand
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