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Normal alveolar epithelial lining fluid contains high levels of glutathione.
- A. Cantin, S. North, R. C. Hubbard, R. Crystal
- Chemistry, Medicine
- Journal of applied physiology
- 1 July 1987
The epithelial cells on the alveolar surface of the human lower respiratory tract are vulnerable to toxic oxidants derived from inhaled pollutants or inflammatory cells. Although these lung cells… Expand
Cystic fibrosis transmembrane conductance regulator function is suppressed in cigarette smokers.
- A. Cantin, J. Hanrahan, +5 authors P. Durie
- American journal of respiratory and critical care…
- 15 May 2006
RATIONALE Cigarette smoke extract inhibits chloride secretion in human bronchial epithelial cells. Oxidants decrease gene expression, protein expression, and function of the cystic fibrosis… Expand
Inflammation in cystic fibrosis lung disease: Pathogenesis and therapy.
- A. Cantin, D. Hartl, M. Konstan, J. Chmiel
- Journal of cystic fibrosis : official journal of…
- 1 July 2015
Lung disease is the major cause of morbidity and mortality in patients with cystic fibrosis (CF). Although CF lung disease is primarily an infectious disorder, the associated inflammation is both… Expand
Staphylococcus aureus sigma B-dependent emergence of small-colony variants and biofilm production following exposure to Pseudomonas aeruginosa 4-hydroxy-2-heptylquinoline-N-oxide
- Gabriel Mitchell, David Lalonde Séguin, +5 authors F. Malouin
- Biology, Medicine
- BMC Microbiology
- 30 January 2010
BackgroundStaphylococcus aureus and Pseudomonas aeruginosa are often found together in the airways of cystic fibrosis (CF) patients. It was previously shown that the P. aeruginosa exoproduct… Expand
Oxidant-mediated epithelial cell injury in idiopathic pulmonary fibrosis.
- A. Cantin, S. North, G. Fells, R. C. Hubbard, R. Crystal
- Medicine, Biology
- The Journal of clinical investigation
- 1 June 1987
Lung inflammatory cells of patients with idiopathic pulmonary fibrosis (IPF) were evaluated for their ability to injure 51Cr-labeled AKD alveolar epithelial cells in the presence and absence of IPF… Expand
Nacystelyn, a novel lysine salt of N-acetylcysteine, to augment cellular antioxidant defence in vitro.
- A. Gillissen, M. Jaworska, +5 authors G. Schultze-Werninghaus
- Respiratory medicine
- 1 March 1997
Nacystelyn (NAL), a recently-developed lysine salt of N-acetylcysteine (NAC), and NAG, both known to have excellent mucolytic capabilities, were tested for their ability to enhance cellular… Expand
Glutathione deficiency in the epithelial lining fluid of the lower respiratory tract in idiopathic pulmonary fibrosis.
- A. Cantin, R. C. Hubbard, R. Crystal
- The American review of respiratory disease
- 1 February 1989
Glutathione (L-gamma-glutamyl-L-cysteinyl-glycine, GSH), a sulfhydryl-containing tripeptide produced by most mammalian cells, is an efficient scavenger of toxic oxidants, including hydrogen peroxide,… Expand
Effect of glutathione aerosol on oxidant-antioxidant imbalance in idiopathic pulmonary fibrosis
Idiopathic pulmonary fibrosis (IPF) is characterised by alveolar inflammation, exaggerated release of oxidants, and subnormal concentrations of the antioxidant glutathione in respiratory epithelial… Expand
Augmentation of glutathione in the fluid lining the epithelium of the lower respiratory tract by directly administering glutathione aerosol.
- R. Buhl, C. Vogelmeier, +5 authors R. Crystal
- Chemistry, Medicine
- Proceedings of the National Academy of Sciences…
- 1 June 1990
Glutathione (GSH), a cysteine-containing tripeptide, functions as an antioxidant, provides cells with cysteine, and is required for optimal function of the immune system. Because the… Expand
Extracellular glutathione suppresses human lung fibroblast proliferation.
- A. Cantin, P. Larivée, R. Bégin
- Biology, Medicine
- American journal of respiratory cell and…
- 1 July 1990
Alveolar epithelial lining fluid glutathione (GSH) is markedly decreased in patients with idiopathic pulmonary fibrosis (IPF). Because patients with IPF have exaggerated numbers of fibroblasts in… Expand