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Pericyte contraction induced by oxidative-nitrative stress impairs capillary reflow despite successful opening of an occluded cerebral artery
TLDR
The findings point to a major but previously not recognized pathophysiological mechanism; ischemia and reperfusion-induced injury to pericytes may impair microcirculatory reflow and negatively affect survival by limiting substrate and drug delivery to tissue already under metabolic stress, despite recanalization of an occluded artery.
Biology of Stem Cells in Human Umbilical Cord Stroma: In Situ and In Vitro Surveys
TLDR
Conclusively, HUCSCs retain their original phenotype in culture without spontaneous differentiation, have a limited lifespan, and bear multipotent stem cell characteristics, and deserve further study to be potentially used in cell‐based therapies.
New records of alien species on the Levantine coast of Turkey
TLDR
Zoobenthic investigations carried out along the Turkish Levantine coast resulted in identification of nine previously unrecorded alien species that are recognized as Erythrean aliens that entered the Mediterranean through the Suez Canal.
Concise Review: Human Umbilical Cord Stroma with Regard to the Source of Fetus‐Derived Stem Cells
TLDR
A review of the published findings so far regarding the nature of human UC stroma with special emphasis on the spatial distribution and functional structure of stromal cells and matrix, which serves as a niche for residing cells, and to assess the in vitro and in vivo experiments in which differential stem cell potencies were evaluated.
Bisphenol-A induces cell cycle delay and alters centrosome and spindle microtubular organization in oocytes during meiosis.
TLDR
One mode of action of BPA is a moderately severe yet reversible delay in the meiotic cell cycle, possibly by a mechanism that degrades centrosomal proteins and thus perturbs the spindle microtubule organization and chromosome segregation.
Reperfusion-Induced Oxidative/Nitrative Injury to Neurovascular Unit After Focal Cerebral Ischemia
TLDR
During reperfusion, intense superoxide, NO, and peroxynitrite formation on microvessels and surrounding end-feet may lead to cerebral hemorrhage and edema by disrupting microvascular integrity.
Persistent Defect in Transmitter Release and Synapsin Phosphorylation in Cerebral Cortex After Transient Moderate Ischemic Injury
TLDR
Data demonstrate that synaptic transmission may be permanently impaired after transient moderate brain injury, and the transmission failure is likely to be caused by presynaptic mechanisms, one of which may be impaired phosphorylation of Presynaptic proteins.
Capillary pericytes express α-smooth muscle actin, which requires prevention of filamentous-actin depolymerization for detection
TLDR
Capillary pericytes do express α-SMA, which rapidly depolymerizes during tissue fixation thus evading detection by immunolabeling, and the existence of a smaller pool of α- SMA in distal capillaryPericytes that is quickly lost by depolyMERization is confirmed.
Centrosome and microtubule dynamics during early stages of meiosis in mouse oocytes.
TLDR
The results show that centrosomes display precisely controlled spatio-temporal changes during the onset of meiotic maturation, suggesting a mechanism by which the proper distribution of centrosomal material during nuclear breakdown and subsequently formation of spindle are regulated in concordance with the nuclear maturation.
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