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Large‐scale identification of serotype 4 Streptococcus pneumoniae virulence factors
Streptococcus pneumoniae (the pneumococcus) is carried in the nasopharynx of healthy individuals, but can spread to other host sites and lead to pneumonia, bacteraemia, otitis media and meningitis.Expand
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The EAL Domain Protein VieA Is a Cyclic Diguanylate Phosphodiesterase*
The newly recognized bacterial second messenger 3′,5′-cyclic diguanylic acid (cyclic diguanylate (c-di-GMP)) has been shown to regulate a wide variety of bacterial behaviors and traits. BiosynthesisExpand
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Cyclic diguanylate (c‐di‐GMP) regulates Vibrio cholerae biofilm formation
While studying virulence gene regulation in Vibrio cholerae during infection of the host small intestine, we identified VieA as a two‐component response regulator that contributes to activatingExpand
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Dual roles of plcA in Listeria monocytogenes pathogenesis
The plcA gene of Listeria monocytogenes encodes a secreted phosphatidylinositol‐speciftc phospholi‐pase C (PI‐PLC). Recent studies have established that transposon mutations within plcA result inExpand
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Bacterial Small-Molecule Signaling Pathways
Bacteria use diverse small molecules for extra- and intracellular signaling. They scan small-molecule mixtures to access information about both their extracellular environment and their intracellularExpand
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Regulation and Temporal Expression Patterns of Vibrio cholerae Virulence Genes during Infection
The temporal expression patterns of the critical Vibrio cholerae virulence genes, tcpA and ctxA, were determined during infection using a recombinase reporter. TcpA was induced biphasically in twoExpand
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Expression and phosphorylation of the Listeria monocytogenes ActA protein in mammalian cells.
Movement of Listeria monocytogenes within infected eukaryotic cells provides a simple model system to study the mechanism of actin-based motility in nonmuscle cells. The actA gene of L. monocytogenesExpand
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A new Vibrio cholerae sRNA modulates colonization and affects release of outer membrane vesicles
We discovered a new small non‐coding RNA (sRNA) gene, vrrA of Vibrio cholerae O1 strain A1552. A vrrA mutant overproduces OmpA porin, and we demonstrate that the 140 nt VrrA RNA represses ompAExpand
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Roles of cyclic diguanylate in the regulation of bacterial pathogenesis.
Cyclic diguanylate (c-di-GMP) is a bacterial second messenger of growing recognition involved in the regulation of a number of complex physiological processes. This review describes the biosynthesisExpand
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Transposon insertion sequencing: a new tool for systems-level analysis of microorganisms
Our knowledge of gene function has increasingly lagged behind gene discovery, hindering our understanding of the genetic basis of microbial phenotypes. Recently, however, massively parallelExpand
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