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Modulation of anxiety through blockade of anandamide hydrolysis
TLDR
The results indicate that anandamide participates in the modulation of emotional states and point to fatty acid amide hydrolase inhibition as an innovative approach to anti-anxiety therapy.
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Control of pain initiation by endogenous cannabinoids
TLDR
It is shown that anandamide attenuates the pain behaviour produced by chemical damage to cutaneous tissue by interacting with CB1-like cannabinoid receptors located outside the CNS, and that locally generated an andamide and PEA may mediate this effect.
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Functional role of high-affinity anandamide transport, as revealed by selective inhibition.
TLDR
The data indicate that carrier-mediated transport may be essential for termination of the biological effects of anandamide, and may represent a potential drug target.
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The Nuclear Receptor Peroxisome Proliferator-Activated Receptor-α Mediates the Anti-Inflammatory Actions of Palmitoylethanolamide
TLDR
Findings indicate that PPAR-α mediates the anti-inflammatory effects of PEA and suggest that this fatty-acid ethanolamide may serve, like its analog OEA, as an endogenous ligand of PPar-α.
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Rapid Broad-Spectrum Analgesia through Activation of Peroxisome Proliferator-Activated Receptor-α
TLDR
It is reported that agonists of the nuclear receptor PPAR-α (peroxisome proliferator-activated receptor-α) suppress pain behaviors induced in mice by chemical tissue injury, nerve damage, or inflammation and may represent a novel class of analgesics.
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Reversal of Dopamine D2 Receptor Responses by an Anandamide Transport Inhibitor
TLDR
The results support a primary role of the endocannabinoid system in the regulation of psychomotor activity and point to anandamide transport as a potential target for neuropsychiatric medicines.
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The search for the palmitoylethanolamide receptor.
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Anxiolytic-Like Properties of the Anandamide Transport Inhibitor AM404
TLDR
A role of anandamide in the regulation of emotion is supported and the an andamide transport system is pointed to as a potential target for anxiolytic drugs.
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The endocannabinoid system as a target for therapeutic drugs.
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Anandamide suppresses pain initiation through a peripheral endocannabinoid mechanism
TLDR
The results suggest that anandamide-mediated signaling at peripheral CB1 receptors controls the access of pain-related inputs to the CNS, and brain-impenetrant FAAH inhibitors, which strengthen this gating mechanism, might offer a new approach to pain therapy.
View on Nature
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