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Medical ethnobotany of the Teribes of Bocas del Toro, Panama.
The recorded medicinal plants were used mainly for fever, various type of pain and inflammation, and the potential value of 26 plants and their traditional uses was elucidated through literature search.
Reproducible molecular networking of untargeted mass spectrometry data using GNPS
This protocol describes how to use GNPS to explore uploaded metabolomics data, and provides step-by-step instructions for creating reproducible, high-quality molecular networks.
Screening antioxidants using LC-MS: case study with cocoa.
A new assay based on liquid chromatography-mass spectrometry (LC-MS) was developed for the identification and quantitative analysis of antioxidants in complex natural product samples such as food extracts, and procyanidins were found to be the most potent antioxidant species.
Screening of Latin American Plants for Cytotoxic Activity
The SRB cytotoxicity assay was used to screen plant extracts, in a collaborative multinational OAS project involving Argentina, Bolivia, Colombia, Costa Rica, Guatemala, Nicaragua and Panama, against breast, lung, and central nervous system human cancer cell lines, finding Piper barbatum, Senna occidentalis, and Blepharocalyx salicifolius.
Identification of shikimate kinase inhibitors among anti-Mycobacterium tuberculosis compounds by LC-MS.
New early discovery stage lead scaffolds targeting the essential protein MtSK that can be further pursued in a rational drug design program for the discovery of more selective antitubercular drugs are reported.
Antimalarial natural products drug discovery in Panama
This review aims to provide an overview of in vitro screening methodologies for antimalarial drug discovery and to present results of this effort in Panama during the last quarter century.
Chemical Adulterants in Herbal Medicinal Products: A Review.
This review provides up to date information on cases of toxicity, major chemical adulterants in herbal medicinal products, and current analytical techniques used for their detection.
Development of an ultrafiltration-liquid chromatography/mass spectrometry (UF-LC/MS) based ligand-binding assay and an LC/MS based functional assay for Mycobacterium tuberculosis shikimate kinase.
This is the first application of UF-LC/MS and LC/MS in the development of ligand-binding and functional assays, respectively as a useful approach to screen MtSK inhibitors.
Isolation and structure elucidation of an isoflavone and a sesterterpenoic acid from Henriettella fascicularis.
A new isoflavone, 4',5,7-trihydroxy-6,8-dimethylisoflavone (1), and a new sesterterpenoic acid (2), together with five known compounds, lichexanthone (3), (-)-pinoresinol (4), betulinic acid,
Development of binding assays to screen ligands for Plasmodium falciparum thioredoxin and glutathione reductases by ultrafiltration and liquid chromatography/mass spectrometry.
The binding assay developed has a potential for automated high-throughput screening to rapidly determine the binding affinity of ligands for these enzymes and is tested as an inhibitor of PfTrxR and PfGR enzymes.