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Functional and Immunological Relevance of Anaplasma marginale Major Surface Protein 1a Sequence and Structural Analysis
P phylogenetic correlation between MSP1a sequence, secondary structure, B-cell epitope composition and tick transmissibility of A. marginale strains was showed and it was proposed that vaccines with a cross-protective capacity based on M SP1a B- cell epitopes should be designed. Expand
Molecular identification and characterization of Anaplasma platys and Ehrlichia canis in dogs in Mexico.
This research identified A. platys by PCR and phylogenetic analysis in dogs from La Comarca Lagunera, a region formed by three municipalities, Torreon, Gomez-Palacio and Lerdo, in the Northern states of Coahuila and Durango, Mexico, and confirmed that the E. canis strains isolated from Mexico belong to a conservative clade of E.Canis and are closely related to strains from USA. Expand
Combination of RT-PCR and proteomics for the identification of Crimean-Congo hemorrhagic fever virus in ticks
The results supported that the CCHFV identified in ticks are genetic variants of the AP92 strain and could potentially result in the appearance of novel viral genotypes with increased pathogenicity and fitness. Expand
Ultrastructure of Ehrlichia mineirensis, a new member of the Ehrlichia genus.
Recently, we reported the in vitro isolation and the molecular characterization of a new species of Ehrlichia (Ehrlichia mineirensis) from haemolymph of Brazilian Rhipicephalus (Boophilus) microplusExpand
Systems Biology of Tissue-Specific Response to Anaplasma phagocytophilum Reveals Differentiated Apoptosis in the Tick Vector Ixodes scapularis
The results showed tissue-specific differences in tick response to infection and revealed differentiated regulation of apoptosis pathways, which will contribute to characterize gene regulation in ticks. Expand
The genus Anaplasma: new challenges after reclassification.
This review focuses on the two most important pathogens: A. marginale, which causes bovine anaplasmosis, and A. phagocytophilum, the aetiologic agent of tick-borne fever in sheep and human granulocytic anaplasmsosis, an emergingtick-borne disease of humans. Expand
Ticks and Tick-Borne Pathogens of the Caribbean: Current Understanding and Future Directions for More Comprehensive Surveillance
The need for innovative and versatile surveillance tools using high-throughput pathogen detection (e.g., high- throughput real-time microfluidic PCR) in large epidemiological surveys will likely improve TBD prevention and control programs in the Caribbean. Expand
Tick-Pathogen Interactions and Vector Competence: Identification of Molecular Drivers for Tick-Borne Diseases
This review provides a comprehensive overview of tick-pathogen molecular interactions for bacteria, viruses, and protozoa affecting human and animal health and suggests some of the similar mechanisms used by the pathogens for infection and transmission by ticks may assist in development of preventative strategies against multiple tick-borne diseases. Expand
Epidemiology and evolution of the genetic variability of Anaplasma marginale in South Africa.
It is confirmed that anaplasmosis is endemic in South Africa and the development of an A. marginale major surface protein 1a (MSP1a)-based vaccine is a proposed control strategy. Expand
Interactions between tick and transmitted pathogens evolved to minimise competition through nested and coherent networks
It is found that the large number of vertebrates in the network contributes to its robustness and persistence, and the structure reduces interspecific competition and allows ample but modular circulation of transmitted pathogens among vertebrates. Expand