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Discovery of Novel Antifungal (1,3)-β-d-Glucan Synthase Inhibitors
Results of natural-product screening by a series of newly developed methods has led to the identification of four acidic terpenoid (1,3)-β-d-glucan synthase inhibitors, which have limited oral bioavailability and in vitro antifungal activity comparable to that of L-733560, a close analogue of MK-0991.
Patterns of antimicrobial activities from soil actinomycetes isolated under different conditions of pH and salinity
Aims: To evaluate the patterns of the production of antimicrobial compounds by diverse collection of actinomycetes isolated from different geographies under alternative conditions of pH and salinity
The discovery of enfumafungin, a novel antifungal compound produced by an endophytic Hormonema species biological activity and taxonomy of the producing organisms.
A new triterpene glycoside is detected, showing an antifungal activity highly potent in vitro against Candida and Aspergillus and with moderate efficacy in an in vivo mouse model of disseminated candidiasis.
Screening of antimicrobial activities in red, green and brown macroalgae from Gran Canaria (Canary Islands, Spain)
Abstract. Extracts from 44 species of seaweed from Gran Canaria (Canary Islands, Spain) were screened for the production of antibacterial and antifungal compounds against a panel of Gram-negative and
Microbial natural products as a source of antifungals.
A selection of antifungal agents in early stages of development, produced by micro-organisms, is summarized in this review and some considerations related to the chemotaxonomy of the producing organisms and some issues relevant to antIFungal drug discovery are discussed.
Endophytic fungi from plants living on gypsum soils as a source of secondary metabolites with antimicrobial activity
Endophytic fungi were isolated from nine plant species growing on gypsum and saline soils in central Spain, showing large differences among isolates from the same species, with respect to their ability to produce metabolites with antimicrobial activity.
Isolation and Structural Determination of Enfumafungin, a Triterpene Glycoside Antifungal Agent That Is a Specific Inhibitor of Glucan Synthesis
Enfumafungin (1) is a hemiacetal, triterpene glycoside that was isolated from a fermentation of Hormonema sp. as a mixture of two interconverting forms. The primary structure of the major component
Leaf micromorphology and anatomy of Myrceugenia rufa (Myrtaceae): An endemic coastal shrub of north-central Chile
The leaf anatomy of M. rufa matches that of other Myrtaceae, such as presence of druses, schizogenous secretory ducts and internal phloem, and confirms an anatomical adaptation to xerophytic environments.
Arundifungin, a novel antifungal compound produced by fungi: biological activity and taxonomy of the producing organisms
A novel acidic steroid, named arundifungin, was purified from a fungal extract obtained from a liquid culture of Arthrinium arundinis collected in Costa Rica, and its antifungal spectrum was comparable to those of echinocandins and papulacandins, preferentially inhibiting the growth of Candida and Aspergillus strains, with very poor activity against Cryptococcus.
Antimicrobial activity of ergokonin A from Trichoderma longibrachiatum
Aims: Natural fungal products were screened for antifungal compounds. The mode of action of one of the hits found and the taxonomy of the producing organism were analysed.