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Role of extracellular dopamine in the initiation and long-term expression of behavioral sensitization to cocaine.
Repeated intermittent administration of cocaine has been shown to sensitize animals to the locomotor-activating effects of this agent. The neurobiochemical basis of this phenomenon, however, remainsExpand
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κ-Opioid Receptor Activation Modifies Dopamine Uptake in the Nucleus Accumbens and Opposes the Effects of Cocaine
Coadministration of κ-opioid receptor agonists (κ-agonists) with cocaine prevents alterations in dialysate dopamine (DA) concentration in the nucleus accumbens (Acb) that occur during abstinence fromExpand
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Overview of Brain Microdialysis
The technique of microdialysis enables sampling and collecting of small‐molecular‐weight substances from the interstitial space. It is a widely used method in neuroscience and is one of the fewExpand
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Delta-Opioid Receptor Antagonists Prevent Sensitization to the Conditioned Rewarding Effects of Morphine
BACKGROUND Functional interactions between mu- and delta-opioid receptors (MOPr and DOPr, respectively) are implicated in morphine tolerance and dependence. The contribution of DOPr to theExpand
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Placentophagia in Humans and Nonhuman Mammals: Causes and Consequences
Afterbirth ingestion by nonhuman mammalian mothers has a number of benefits: (1) increasing the interaction between the mother and infant; (2) potentiating pregnancy-mediated analgesia in theExpand
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Sensitization to the conditioned rewarding effects of morphine and cocaine: differential effects of the kappa-opioid receptor agonist U69593.
The ability of the kappa-opioid receptor agonist U69593 to attenuate the sensitization and cross-sensitization which develops to the conditioned rewarding effects of morphine and cocaine was examinedExpand
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Modulation of pre‐ and postsynaptic dopamine D2 receptor function by the selective kappa‐opioid receptor agonist U69593
The repeated administration of selective kappa‐opioid receptor agonists prevents the locomotor activation produced by acute cocaine administration and the development of cocaine‐induced behavioralExpand
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Long-Term Reduction in Ventral Tegmental Area Dopamine Neuron Population Activity Following Repeated Stimulant or Ethanol Treatment
BACKGROUND Drugs of abuse exert profound effects on the mesolimbic/mesocortical dopaminergic (DA) systems. Few studies have investigated the long-term adaptations in ventral tegmental area (VTA) DAExpand
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Diet-induced obesity: dopamine transporter function, impulsivity and motivation
Objective:A rat model of diet-induced obesity (DIO) was used to determine dopamine transporter (DAT) function, impulsivity and motivation as neurobehavioral outcomes and predictors ofExpand
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Overview of Microdialysis
The technique of microdialysis enables the monitoring of neurotransmitters and other molecules in the extracellular environment. This method has undergone several modifications and is now widely usedExpand
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