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An ecological resilience perspective on cancer: insights from a toy model
TLDR
We propose an ecological resilience point of view on cancer based on the analysis of a simple ODE model. Expand
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Basins of attraction of the classic model of competition between two populations
Abstract In this paper we revisit the classic Lotka–Volterra model of competition between two populations and present some new results on the regime of bistability presented by this model. Initially,Expand
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Reduced tyrosine kinase inhibitor dose is predicted to be as effective as standard dose in chronic myeloid leukemia: a simulation study based on phase III trial data
Continuing tyrosine kinase inhibitor (TKI)-mediated targeting of the BCR-ABL1 oncoprotein is the standard therapy for chronic myeloid leukemia (CML) and allows for a sustained disease control in theExpand
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Fitting the Incidence Data from the City of Campinas, Brazil, Based on Dengue Transmission Modellings Considering Time-Dependent Entomological Parameters
Four time-dependent dengue transmission models are considered in order to fit the incidence data from the City of Campinas, Brazil, recorded from October 1st 1995 to September 30th 2012. TheExpand
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Abiotic Effects on Population Dynamics of Mosquitoes and Their Influence on Dengue Transmission
Dengue incidence is dependent on abiotic factors that directly affect the population dynamics of mosquitoes with serious implications for dengue transmission. By using estimated entomologicalExpand
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Model-Based Inference and Classification of Immunologic Control Mechanisms from TKI Cessation and Dose Reduction in Patients with CML
This mathematical modeling approach provides strong evidence that different immunological configurations in patients with CML determine their response to therapy cessation and that dose reductionsExpand
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Modeling dynamics for oncogenesis encompassing mutations and genetic instability.
  • A. C. Fassoni, H. Yang
  • Biology, Medicine
  • Mathematical medicine and biology : a journal of…
  • 13 June 2019
Tumorigenesis has been described as a multistep process, where each step is associated with a genetic alteration, in the direction to progressively transform a normal cell and its descendants into aExpand
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MINIMAL MODEL FOR METRONOMIC CHEMOTHERAPY: MATHEMATICAL ANALYSIS AND MEDICAL IMPLICATIONS
In the last years, a new era in the fight against cancer has began, fueled by biochemical deciphering of many sub and intracelular interactions involved in the tumor microenvironment, and by newExpand
Inferring immunological control mechanisms from TKI dose alterations in CML patients
Recent clinical findings in chronic myeloid leukemia (CML) patients suggest that the risk of molecular recurrence after stopping tyrosine kinase inhibitors (TKI) treatment substantially depend on anExpand