• Publications
  • Influence
Neurodegenerative diseases and oxidative stress
Oxidative stress has been implicated in the progression of Alzheimer's disease, Parkinson's disease and amyotrophic lateral sclerosis and different strategies, including novel metal–protein attenuating compounds aimed at a variety of targets have shown promise in clinical studies.
The neurobiology of zinc in health and disease
The use of zinc in medicinal skin cream was mentioned in Egyptian papyri from 2000 BC, and the number of biological functions, health implications and pharmacological targets that are emerging for zinc indicate that it might turn out to be 'the calcium of the twenty-first century'.
Soluble pool of Aβ amyloid as a determinant of severity of neurodegeneration in Alzheimer's disease
The genetic evidence strongly supports the view that Aβ amyloid production is central to the cause of Alzheimer's disease, and the concept of several interacting pools of Aβ, that is, a large relatively static insoluble pool that is derived from a constantly turning over smaller soluble pool, is supported.
The Australian Imaging, Biomarkers and Lifestyle (AIBL) study of aging: methodology and baseline characteristics of 1112 individuals recruited for a longitudinal study of Alzheimer's disease
The participants comprising the AIBL cohort represent a group of highly motivated and well-characterized individuals who represent a unique resource for the study of AD.
Zinc in the physiology and pathology of the CNS
The recent development of powerful tools, including zinc-sensitive fluorescent probes, selective chelators and genetically modified animal models, has brought a deeper understanding of the roles of this cation as a crucial intra- and intercellular signalling ion of the CNS.
The A beta peptide of Alzheimer's disease directly produces hydrogen peroxide through metal ion reduction.
It is shown that human A beta directly produces hydrogen peroxide (H2O2) by a mechanism that involves the reduction of metal ions, Fe(III) or Cu(II), setting up conditions for Fenton-type chemistry.
The metallobiology of Alzheimer's disease
  • A. Bush
  • Biology
    Trends in Neurosciences
  • 1 April 2003