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Sex Differences in Morphine Analgesia: An Experimental Study in Healthy Volunteers
BackgroundAnimal and human studies indicate the existence of important sex-related differences in opioid-mediated behavior. In this study the authors examined the influence of morphine onExpand
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Pharmacodynamic Interaction between Propofol and Alfentanil When Given for Induction of Anesthesia
Background Propofol and alfentanil often are combined during induction of anesthesia. However, the interaction between these agents during induction has not been studied in detail. The influence ofExpand
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Propofol Reduces Perioperative Remifentanil Requirements in a Synergistic Manner: Response Surface Modeling of Perioperative Remifentanil–Propofol Interactions
Background Remifentanil is often combined with propofol for induction and maintenance of total intravenous anesthesia. The authors studied the effect of propofol on remifentanil requirements forExpand
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The Pharmacodynamic Interaction of Propofol and Alfentanil during Lower Abdominal Surgery in Women
Background Propofol and alfentanil are frequently combined to provide general anesthesia. The purpose of this study was to characterize the pharmacodynamic interaction between propofol and alfentanilExpand
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The effect of age on serum concentrations of albumin and alpha 1-acid glycoprotein.
1. Human serum albumin (HSA) concentrations and alpha 1-acid glycoprotein (AAG) concentrations were measured in 68 subjects, 35 males and 33 females, aged 20-90 years without evidence of acute orExpand
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Mixed-effects Modeling of the Influence of Alfentanil on Propofol Pharmacokinetics
BackgroundThe influence of alfentanil on the pharmacokinetics of propofol is poorly understood. Therefore, the authors studied the effect of a pseudo–steady state concentration of alfentanil on theExpand
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Propofol Alters the Pharmacokinetics of Alfentanil in Healthy Male Volunteers
Background The influence of propofol on the pharmacokinetics of alfentanil is poorly understood. The authors therefore studied the effect of a pseudo–steady state concentration of propofol on theExpand
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Clinical Pharmacokinetics of Epidural and Spinal Anaesthesia
  • A. Burm
  • Medicine
  • Clinical pharmacokinetics
  • 1 May 1989
SummaryEpidural and spinal anaesthesia results from the interaction of local anaesthetics with nerve structures, primarily those located within the subarachnoid space. Local anaesthetics can reachExpand
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Performance of Computer-Controlled Infusion of Propofol: An Evaluation of Five Pharmacokinetic Parameter Sets
Computer-controlled infusion of propofol is used with increasing frequency for the induction and maintenance of anesthesia. The performance of computer-controlled infusion devices is highly dependentExpand
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