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- Publications
- Influence
Sex Differences in Morphine Analgesia: An Experimental Study in Healthy Volunteers
- E. Sarton, E. Olofsen, +6 authors A. Dahan
- Medicine
- Anesthesiology
- 1 November 2000
BackgroundAnimal and human studies indicate the existence of important sex-related differences in opioid-mediated behavior. In this study the authors examined the influence of morphine on… Expand
Pharmacodynamic Interaction between Propofol and Alfentanil When Given for Induction of Anesthesia
- J. Vuyk, F. Engbers, +4 authors J. Bovill
- Medicine
- Anesthesiology
- 1 February 1996
Background Propofol and alfentanil often are combined during induction of anesthesia. However, the interaction between these agents during induction has not been studied in detail. The influence of… Expand
Propofol Reduces Perioperative Remifentanil Requirements in a Synergistic Manner: Response Surface Modeling of Perioperative Remifentanil–Propofol Interactions
- M. Mertens, E. Olofsen, F. Engbers, A. Burm, J. Bovill, J. Vuyk
- Medicine
- Anesthesiology
- 1 August 2003
Background Remifentanil is often combined with propofol for induction and maintenance of total intravenous anesthesia. The authors studied the effect of propofol on remifentanil requirements for… Expand
Propofol Anesthesia and Rational Opioid Selection: Determination of Optimal EC50‐EC95 Propofol‐Opioid Concentrations that Assure Adequate Anesthesia and a Rapid Return of Consciousness
- J. Vuyk, M. Mertens, E. Olofsen, A. Burm, J. Bovill
- Medicine
- Anesthesiology
- 1 December 1997
The Pharmacodynamic Interaction of Propofol and Alfentanil during Lower Abdominal Surgery in Women
- J. Vuyk, T. Lim, F. Engbers, A. Burm, A. Vletter, J. Bovill
- Medicine
- Anesthesiology
- 1 July 1995
Background Propofol and alfentanil are frequently combined to provide general anesthesia. The purpose of this study was to characterize the pharmacodynamic interaction between propofol and alfentanil… Expand
The effect of age on serum concentrations of albumin and alpha 1-acid glycoprotein.
- B. Veering, A. Burm, J. Souverijn, J. M. Serree, J. Spierdijk
- Medicine
- British journal of clinical pharmacology
- 1 February 1990
1. Human serum albumin (HSA) concentrations and alpha 1-acid glycoprotein (AAG) concentrations were measured in 68 subjects, 35 males and 33 females, aged 20-90 years without evidence of acute or… Expand
Mixed-effects Modeling of the Influence of Alfentanil on Propofol Pharmacokinetics
- M. Mertens, E. Olofsen, A. Burm, J. Bovill, J. Vuyk
- Medicine
- Anesthesiology
- 1 April 2004
BackgroundThe influence of alfentanil on the pharmacokinetics of propofol is poorly understood. Therefore, the authors studied the effect of a pseudo–steady state concentration of alfentanil on the… Expand
Propofol Alters the Pharmacokinetics of Alfentanil in Healthy Male Volunteers
- M. Mertens, J. Vuyk, E. Olofsen, J. Bovill, A. Burm
- Medicine
- Anesthesiology
- 1 June 2001
Background The influence of propofol on the pharmacokinetics of alfentanil is poorly understood. The authors therefore studied the effect of a pseudo–steady state concentration of propofol on the… Expand
Clinical Pharmacokinetics of Epidural and Spinal Anaesthesia
- A. Burm
- Medicine
- Clinical pharmacokinetics
- 1 May 1989
SummaryEpidural and spinal anaesthesia results from the interaction of local anaesthetics with nerve structures, primarily those located within the subarachnoid space. Local anaesthetics can reach… Expand
Performance of Computer-Controlled Infusion of Propofol: An Evaluation of Five Pharmacokinetic Parameter Sets
- J. Vuyk, F. Engbers, A. Burm, A. Vletter, J. Bovill
- Medicine
- Anesthesia and analgesia
- 1 December 1995
Computer-controlled infusion of propofol is used with increasing frequency for the induction and maintenance of anesthesia. The performance of computer-controlled infusion devices is highly dependent… Expand