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Heparin versus 0.9% sodium chloride intermittent flushing for prevention of occlusion in central venous catheters in adults.
BACKGROUND Heparin intermittent flushing is a standard practice in the maintenance of patency in central venous catheters. However, we could find no systematic review examining its effectiveness andExpand
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  • Open Access
Heparin versus 0.9% sodium chloride locking for prevention of occlusion in central venous catheters in adults.
BACKGROUND Intermittent locking of central venous catheters (CVCs) is undertaken to help maintain their patency. There are systematic variations in care: some practitioners use heparin (at differentExpand
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Oxygen therapy for acute myocardial infarction.
BACKGROUND Oxygen (O2) is widely used in people with acute myocardial infarction (AMI). Previous systematic reviews concluded that there was insufficient evidence to know whether oxygen reduced,Expand
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A smartphone intervention for adolescent obesity: study protocol for a randomised controlled non-inferiority trial
BackgroundThere are few evidence-based mobile health solutions for treating adolescent obesity. The primary aim of this parallel non-inferiority trial is to assess the effectiveness of anExpand
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  • Open Access
Certolizumab pegol (CDP870) for rheumatoid arthritis in adults.
BACKGROUND TNF-alpha inhibitors have been shown to reduce the risk of joint damage and improve physical function and quality of life in people with rheumatoid arthritis (RA). This is the firstExpand
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  • Open Access
Systematic reviews of specialist epilepsy services
BACKGROUND Concern has been expressed over UK epilepsy service standards but the most clinically effective model of care is unknown. OBJECTIVE To systematically review the current evidence onExpand
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  • Open Access
Absence of Nerve – muscle Interaction Influences the Survival of Developing Motoneurons
Following sciatic nerve crush at birth, ∼70% of motoneurons to the soleus and 60% of motoneurons to the tibialis anterior (TA) and to the extensor digitorum longus (EDL) die. However, following nerveExpand
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Etanercept for the treatment of rheumatoid arthritis.
BACKGROUND Etanercept is a soluble tumour necrosis factor alpha-receptor disease-modifying anti-rheumatic drug (DMARD) for the treatment of rheumatoid arthritis (RA). OBJECTIVES The purpose of thisExpand
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Colchicine for children with pericarditis: systematic review of clinical studies
Objective To review the evidence for the efficacy and safety of colchicine in children with pericarditis. Design Systematic review. Search strategy The following databases were searched for studiesExpand
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  • Open Access
Certolizumab pegol (CDP870) for rheumatoid arthritis in adults.
BACKGROUND Tumour necrosis factor (TNF)-alpha inhibitors are beneficial for the treatment of rheumatoid arthritis (RA) in terms of reducing the risk of joint damage, improving physical function andExpand
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  • Open Access