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Unusual Organisms Causing Intravenous Line Infections in Compromised Hosts: I. Bacterial and Algal Infections
Prevention of Diet-Induced Metabolic Dysregulation, Inflammation, and Atherosclerosis in Ldlr−/− Mice by Treatment With the ATP-Citrate Lyase Inhibitor Bempedoic Acid
- Joshua P Samsoondar, A. Burke, +6 authors M. Huff
- Biology, Medicine
- Arteriosclerosis, thrombosis, and vascular…
- 1 April 2017
Objective— Bempedoic acid (ETC-1002, 8-hydroxy-2,2,14,14-tetramethylpentadecanedioic acid) is a novel low-density lipoprotein cholesterol–lowering compound. In animals, bempedoic acid targets the… Expand
“It’s really fascinating work”: Differences in Evaluative Adjectives across Academic Registers
The properties of academic speech are much less well known than those of academic writing. As part of an attempt to redress this imbalance, this paper investigates evaluative adjectives and their… Expand
PCSK9: Regulation and Target for Drug Development for Dyslipidemia.
- A. Burke, Jacqueline S. Dron, R. Hegele, M. Huff
- Medicine, Biology
- Annual review of pharmacology and toxicology
- 6 January 2017
Proprotein convertase subtilisin/kexin type-9 (PCSK9) is a secreted zymogen expressed primarily in the liver. PCSK9 circulates in plasma, binds to cell surface low-density lipoprotein (LDL)… Expand
Intervention with citrus flavonoids reverses obesity and improves metabolic syndrome and atherosclerosis in obese Ldlr−/− mice[S]
Obesity and its associated metabolic dysfunction and cardiovascular disease risk represent a leading cause of adult morbidity worldwide. Currently available pharmacological therapies for obesity have… Expand
Regression of atherosclerosis: lessons learned from genetically modified mouse models
Purpose of review Regression, or reversal, of atherosclerosis has become an important clinical objective. The development of consistent models of murine atherosclerosis regression has accelerated… Expand
Naringenin Supplementation to a Chow Diet Enhances Energy Expenditure and Fatty Acid Oxidation, and Reduces Adiposity in Lean, Pair‐Fed Ldlr−/− Mice
- A. Burke, D. Telford, J. Y. Edwards, B. Sutherland, C. Sawyez, M. Huff
- Biology, Medicine
- Molecular nutrition & food research
- 1 March 2019
SCOPE Naringenin is a citrus-derived flavonoid that has potent lipid-lowering and insulin-sensitizing effects in obese mouse models of metabolic dysfunction. However, in these models, a significant… Expand
Citrus Flavonoids as Regulators of Lipoprotein Metabolism and Atherosclerosis.
Citrus flavonoids are polyphenolic compounds with significant biological properties. This review summarizes recent advances in understanding the ability of citrus flavonoids to modulate lipid… Expand
Naringenin prevents obesity, hepatic steatosis, and glucose intolerance in male mice independent of fibroblast growth factor 21.
The molecular mechanisms and metabolic pathways whereby the citrus flavonoid, naringenin, reduces dyslipidemia and improves glucose tolerance were investigated in C57BL6/J wild-type mice and… Expand
ATP-citrate lyase: genetics, molecular biology and therapeutic target for dyslipidemia
Purpose of review ATP-citrate lyase (ACLY) has re-emerged as a drug target for LDL cholesterol (LDL-C) lowering. We review ACLY as a therapeutic strategy, its genetics, its molecular and cellular… Expand