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O-(dihydrobenzofuranyl)-dibenzo-α-pyrones from Umtiza Listerana
Abstract The novel metabolites (2′S,3′R)-3,10-dihydroxy-9-O-(6′-hydroxy-2′-hydroxymethyldihydrofuran-3-yl)-dibenz-[b,d]-pyran-6-one and its 5′,6′-dihydroxy analogue are accompanied in the heartwood… Expand
Mechanism-based inhibitors of prostaglandin omega-hydroxylase: (R)- and (S)-12-hydroxy-16-heptadecynoic acid and 2,2-dimethyl-12-hydroxy-16-heptadecynoic acid.
- A. Burger, J. Clark, M. Nishimoto, A. Muerhoff, B. Masters, P. Ortiz de Montellano
- Chemistry, Medicine
- Journal of medicinal chemistry
- 14 May 1993
2,2-Dimethyl-12-hydroxy-16-heptadecynoic acid, an analogue that cannot undergo beta-oxidation, has been synthesized as a potential in vivo inhibitor of the enzyme and has been shown to inactivate the purified enzyme with KI = 4.9 microM and t1/2 = 1.0 min. Expand
Homeostatic derangement in the CBA rodent host during the growth of the CaNT tumor.
- N. de Villiers, A. Burger, H. Smith, D. Szeinfeld
- Biology, Medicine
- Cancer biochemistry biophysics
- 1 September 1993
An increase of hexokinase and lactate dehydrogenase activities with tumor volume, coupled with the decline of oxygen consumption are shown in this work, reflecting an increase in the glucose metabolism rate and thus, energy expenditure of the host. Expand