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- A. Bull
- Environmental ScienceBiodiversity & Conservation
From time-to-time Biodiversity and Conservation will publish special theme issues and this, the first, is devoted to microorganisms. Only very recently has consideration of microorganisms and their…
New primers for the class Actinobacteria: application to marine and terrestrial environments.
- J. Stach, L. Maldonado, A. Ward, M. Goodfellow, A. Bull
- BiologyEnvironmental microbiology
- 1 October 2003
The proposition that current culture-based techniques drastically underestimate the diversity of Actinobacteria in the environment is reinforced and the need to evaluate taxon-specific primers regularly is highlighted in line with improvements in databases holding 16S rDNA sequences.
Salinispora arenicola gen. nov., sp. nov. and Salinispora tropica sp. nov., obligate marine actinomycetes belonging to the family Micromonosporaceae.
- L. Maldonado, W. Fenical, M. Goodfellow
- BiologyInternational journal of systematic and…
- 1 September 2005
A taxonomic study was carried out to clarify the taxonomy of representatives of a group of marine actinomycetes previously designated MAR 1 and considered to belong to the family Micromonosporaceae, which contains two species recognized using a range of genotypic and phenotypic criteria.
Search and Discovery Strategies for Biotechnology: the Paradigm Shift
This review examines the paradigm shift from traditional biology to bioinformatics that is revolutionizing exploitable biology and reinforces the view that innovative microbiology is essential for releasing the potential of microbial diversity for biotechnology penetration throughout industry.
Marine actinobacteria: new opportunities for natural product search and discovery.
Diversity of culturable actinomycetes in hyper-arid soils of the Atacama Desert, Chile
The results of this study support the view that arid desert soils constitute a largely unexplored repository of novel bacteria, while the high incidence of non-ribosomal peptide synthase genes in isolates recommend them as promising material in screening for new bioactive natural products.
Marine actinomycetes as a source of novel secondary metabolites
New marine members of the rare genus Verrucosispora seem to be a promising source for novel bioactive secondary metabolites as shown in the case of the abyssomicin producing strain AB-18-032.
Constraints on the transport and glycosylation of recombinant IFN-gamma in Chinese hamster ovary and insect cells.
Although the limitations on intracellular transport and secretion of recombinant proteins in mammalian and insect cells are similar, N-glycan processing in Sf insect cells is limited, and that genetic modification of N-behavioural processing in these insect cell lines will be constrained by substrate availability to terminal galactosylation.
Statistical Approaches for Estimating Actinobacterial Diversity in Marine Sediments
- J. Stach, L. Maldonado, D. Masson, A. Ward, M. Goodfellow, A. Bull
- Environmental ScienceApplied and Environmental Microbiology
- 1 October 2003
Investigating bacterial diversity in a deep-sea sediment found that genetic diversity decreased with sediment depth and that each sediment community harbored unique phylogenetic lineages; it was also shown that even nonconservative OTU definitions result in severe underestimation of species richness.
Abyssomicins, inhibitors of the para-aminobenzoic acid pathway produced by the marine Verrucosispora strain AB-18-032.
A screening method was established to detect inhibitors of the biosynthetic pathways of aromatic amino acids and para-aminobenzoic acid, the precursor of folic acid, using an agar plate diffusion…