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Fumaric acid esters exert neuroprotective effects in neuroinflammation via activation of the Nrf2 antioxidant pathway.
The ability of dimethylfumarate to activate nuclear factor (erythroid-derived 2)-related factor 2 may offer a novel cytoprotective modality that further augments the natural antioxidant responses in multiple sclerosis tissue and is not yet targeted by other multiple sclerosis therapies. Expand
Cytochrome P450-mediated metabolism of the HIV-1 protease inhibitor ritonavir (ABT-538) in human liver microsomes.
The results of this study indicate the potential for in vivo inhibition of the metabolism by ritonavir of drugs that are CYP3A, CYP2D6 and, to a lesser extent, CyP2C9/10 substrates. Expand
Metabolism and disposition of the HIV-1 protease inhibitor ritonavir (ABT-538) in rats, dogs, and humans.
Radio-HPLC analysis of bile, feces, and urine from all three species indicated extensive metabolism of ritonavir to a number of oxidative metabolites, some being species-specific, and all involving metabolism at the terminal functional groups of the molecule. Expand
Ethyl-substituted erythromycin derivatives produced by directed metabolic engineering.
A previously unknown chemical structure, 6-desmethyl-6-ethylerythromycin A (6-ethylErA), was produced through directed genetic manipulation of the erythromycin (Er)-producing organismExpand
Group B streptococci inactivate complement component C5a by enzymic cleavage at the C-terminus.
Plasma-desorption m.s. of rC5a inactivated by GBS 7360 showed that the GBS cleaved the rC 5a between histidine-67 and lysine-68 near the C-terminus of C5a, consistent with the known critical role of the C -terminus in C 5a activation of human PMNs. Expand
Carbohydrate composition and presence of a fucose-protein linkage in recombinant human pro-urokinase.
A new post-translational modification site in the growth factor domain of urinary type plasminogen activator has been identified and an equimolar ratio of peptide and fucose in the glycopeptide is showed. Expand
Pacidamycins, a novel series of antibiotics with anti-Pseudomonas aeruginosa activity. II. Isolation and structural elucidation.
A novel class of antibiotics was isolated from cultures of Streptomyces coeruleorubidus strain AB 1183F-64. The antimicrobial activity of the pacidamycins is selective against Pseudomonas aeruginosa.Expand
Sequence analysis of polypeptides by collision activated dissociation on a triple quadrupole mass spectrometer.
A new approach to the direct sequencing of oligopeptides in complex mixtures using isobutane chemical ionization for sequence analysis of neuropeptides at the picomole level is described. Expand
Finding useful biomarkers for Parkinson’s disease
The recent advent of an “ecosystem” of shared biosample biorepositories and data sets will aid efforts to define biomarkers for Parkinson’s disease. The recent advent of an “ecosystem” of sharedExpand
Inhibition of p56(lck) tyrosine kinase by isothiazolones.
A similar mechanism of sulfhydryl oxidation leading to p56(lck) inhibition, described in this report, may occur in the intact T cell and may underlie certain T cell pathologies. Expand