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- Publications
- Influence
Restricted antigenic variability of the epitope recognized by the neutralizing gp41 antibody 2F5
- M. Purtscher, A. Trkola, +7 authors H. Katinger
- Biology, Medicine
- AIDS
- 1 June 1996
Objective To investigate whether variations of the conserved gp41 amino-acid sequence ELDKWA affect its binding or neutralization by monoclonal antibody (MAb) 2F5. Design and methods Neutralization… Expand
Mapping of FVIII inhibitor epitopes using cellulose-bound synthetic peptide arrays.
- E. Kopecky, Sabine Greinstetter, I. Pabinger, A. Buchacher, J. Roemisch, A. Jungbauer
- Chemistry, Medicine
- Journal of immunological methods
- 20 January 2006
Epitope mapping using antibodies against factor VIII (FVIII) has been performed using blotting techniques with truncated and/or digested FVIII molecules. Here, we focused on the precise mapping of… Expand
Effect of oriented or random PEGylation on bioactivity of a factor VIII inhibitor blocking peptide
- E. Kopecky, Sabine Greinstetter, I. Pabinger, A. Buchacher, J. Roemisch, A. Jungbauer
- Medicine, Chemistry
- Biotechnology and bioengineering
- 5 March 2006
Peptides as therapeutic substances are efficient agents in the treatment of several diseases. However, they often have to be chemically modified in order to be suited as therapeutic agent.… Expand
Combinatorial peptides directed to inhibitory antibodies against human blood clotting factor VIII.
- E. Kopecky, Sabine Greinstetter, I. Pabinger, A. Buchacher, J. Roemisch, A. Jungbauer
- Medicine
- Thrombosis and haemostasis
- 17 October 2005
The development of antibodies against blood clotting factor VIII is a major complication affecting 20-30% of hemophilia A patients receiving replacement with FVIII concentrates. This study… Expand
Effects of ultra-/diafiltration conditions on present aggregates in human immunoglobulin G preparations
- K. Ahrer, A. Buchacher, G. Iberer, A. Jungbauer
- Chemistry
- 5 April 2006
Small traces of aggregates may cause reduced stability of human immunoglobulin G preparations. Ultra-/diafiltration as last step before formulation could also contribute to aggregate formation or… Expand
Anforderung an ein IGIV der 4. Generation: Eigenschaften von Octagam; Präparatekurzprofil
- A. Buchacher, L. Biesert, B. Helmich
- Medicine
- 1996
Electrophoretic analyses of clotting factor VIII concentrates
- K. Pock, A. Jungbauer, C. Kannicht, K. Löster, A. Buchacher, D. Josić
- Chemistry
- 19 October 1998
Abstract Preparations of clotting factor VIII (FVIII) are complex protein mixtures, regardless of whether they are made by genetically engineered cells or isolated from human plasma. Commercially… Expand
PRODUCTION OF THE HIV-1 NEUTRALISING HUMAN MONOCLONAL ANTIBODY 2F5: STIRRED TANK VERSUS FLUIDIZED BED CULTURE
- M. Reiter, A. Buchacher, +6 authors H. Katinger
- Chemistry
- 1994
ABSTRACT The performance of a 6 litre stirred tank reactor and a fluidized bed reactor operated with 2 litre macroporous PolyporE beads have been compared. Under controlled perfusion conditions the… Expand
Long-Term Stability Of Continuously Perfused Animal Cells Immobilized On Novel Macroporous Microcarriers
- H. Katinger, A. Assadian, +10 authors N. Zach
- Chemistry
- 1996
The ultimate goal of optimizing biological production is the establishment of simple, safe, cheap, consistent, and easily manageable production systems. Various complicated techniques have been used… Expand