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Differential Expression and Sequence-specific Interaction of Karyopherin α with Nuclear Localization Sequences*
- S. Nadler, D. Tritschler, O. Haffar, J. Blake, A. Bruce, J. Cleaveland
- Biology, Medicine
- The Journal of Biological Chemistry
- 14 February 1997
It is found that the karyopherins hSRP1 and hSRp1α are differentially expressed in various leukocyte cell lines and could be induced in normal human peripheral blood lymphocytes, providing evidence for multiple levels of control of the nuclear import process. Expand
Oncostatin M is a member of a cytokine family that includes leukemia-inhibitory factor, granulocyte colony-stimulating factor, and interleukin 6.
It is proposed that OSM, LIF, G-CSF, and IL-6 are structurally related members of a cytokine family that have in common the ability to modulate differentiation of a variety of cell types. Expand
Mutations of the flavin-containing monooxygenase gene (FMO3) cause trimethylaminuria, a defect in detoxication.
It is shown that mutations in the human flavin-containing monooxygenase isoform 3 gene ( FMO3) impair N -oxygenation of xenobiotics and are responsible for the trimethylaminuria phenotype. Expand
Oncostatin M binds the high-affinity leukemia inhibitory factor receptor.
Since the presence of high-affinity LIF receptors correlates with the biological activity of LIF on a wide range of target cells, it is predicted that OSM should have similar effects on LIF-responsive cells. Expand
Oncostatin M (OSM) inhibits the differentiation of pluripotent embryonic stem cells in vitro.
It is demonstrated that human recombinant OSM is similar to LIF in its ability to inhibit the differentiation of MBL-5 murine ES cells cultured in vitro, which implicate OSM as a developmental regulatory factor for embryonic stem cells in vivo. Expand
Oncostatin-M: a new bone active cytokine that activates osteoblasts and inhibits bone resorption.
- P. R. Jay, M. Centrella, J. Lorenzo, A. Bruce, M. Horowitz
- Biology, Medicine
- 1 April 1996
These data represent the first report of OSM's effects on bone cell function and indicate that, like some other members of the LIF/interleukin-6 subfamily, OSM has potent bone regulatory activity. Expand
Next-Generation Sequence Analysis of the Genome of RFHVMn, the Macaque Homolog of Kaposi's Sarcoma (KS)-Associated Herpesvirus, from a KS-Like Tumor of a Pig-Tailed Macaque
Sequence comparisons indicated that RFHVMn and KSHV developed in long-term synchrony with the evolution of their hosts, and both viruses phylogenetically group within the RV1 lineage of Old World primate rhadinoviruses. Expand
Oncostatin M is a differentiation factor for myeloid leukemia cells.
OSM can induce the differentiation of the myeloblastic M1 murine leukemia cells into macrophage-like cells and the existence of an OSM-specific receptor was confirmed by both growth inhibition and competition binding assays on A375 human melanoma cells. Expand
Development of a real-time QPCR assay for the detection of RV2 lineage-specific rhadinoviruses in macaques and baboons
A real-time quantitative PCR (QPCR) assay using a TaqMan probe to differentially detect and quantitate members of the rhadinovirus-2 (RV2) lineage, found in a variety of macaque species commonly used for biomedical research. Expand
Macaque Homologs of EBV and KSHV Show Uniquely Different Associations with Simian AIDS-related Lymphomas
The data suggest etiological roles for both lymphocryptoviruses and RV2 rhadinovirus in the development of simian AIDS-associated lymphomas and indicate that the virus-infected neoplastic lymphoid cells are derived from different lymphocyte lineages and differentiation stages. Expand