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Reactive oxygen species and vascular biology: implications in human hypertension
TLDR
The potential role of oxidative stress in human hypertension is focused on and a plethora of data implicating oxidative stress as a causative factor in experimental hypertension is highlighted.
Oxidative Stress and Hypertension: Current Concepts
TLDR
Current insights are provided on the mechanisms of the generation of reactive oxygen species and the vascular effects of oxidative stress and the significance of oxidative damage in experimental and clinical hypertension.
Role of Elastin in Spontaneously Hypertensive Rat Small Mesenteric Artery Remodelling
TLDR
Differences in elastin organisation are a central element in small artery remodelling in hypertension and informs hypertensive remodelling.
Reciprocal relationship between reactive oxygen species and cyclooxygenase-2 and vascular dysfunction in hypertension.
TLDR
The excess of ROS from NAD(P)H Oxidase and/or mitochondria and the increased vascular COX-2/TP receptor axis act in concert to induce vascular dysfunction and hypertension.
Aerobic exercise reduces oxidative stress and improves vascular changes of small mesenteric and coronary arteries in hypertension
TLDR
The effects of aerobic exercise training in vascular remodelling and in the mechanical and functional alterations of coronary and small mesenteric arteries from spontaneously hypertensive rats (SHR) are investigated.
NOX isoforms and reactive oxygen species in vascular health.
TLDR
This work reviews the current understanding of NOX signaling and regulatory mechanisms related to vascular health and disease and distinguishes each isoform by the specific catalytic subunit, interacting proteins, and subcellular localization.
Nitric oxide mediates aortic disease in mice deficient in the metalloprotease Adamts1 and in a mouse model of Marfan syndrome
TLDR
It is shown that Adamts1 is a major mediator of vascular homeostasis, and a possible causative role for the ADAMTS1–NOS2 axis in human TAAD is uncovered and warrant evaluation of NOS2 inhibitors for therapy.
Adipocytes Produce Aldosterone Through Calcineurin-Dependent Signaling Pathways: Implications in Diabetes Mellitus–Associated Obesity and Vascular Dysfunction
TLDR
Functionally adipocyte-derived aldosterone regulates adipocyte differentiation and vascular function in an autocrine and paracrine manner, respectively.
Increased anandamide induced relaxation in mesenteric arteries of cirrhotic rats: role of cannabinoid and vanilloid receptors
TLDR
It is indicated that anandamide is a selective splanchnic vasodilator in cirrhosis which predominantly acts via interaction with two different types of receptors, CB1 and TRPV1 receptors, which are mainly located in perivascular sensory nerve terminals of the mesenteric resistance arteries of these animals.
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