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Mps1 Phosphorylates Borealin to Control Aurora B Activity and Chromosome Alignment
Maintenance of chromosomal stability relies on coordination between various processes that are critical for proper chromosome segregation in mitosis. Here we show that monopolar spindle 1 (Mps1)Expand
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Redox-sensitive cysteines bridge p300/CBP-mediated acetylation and FoxO4 activity.
Cellular damage invoked by reactive oxygen species plays a key role in the pathobiology of cancer and aging. Forkhead box class O (FoxO) transcription factors are involved in various cellularExpand
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Chromosomal Instability by Inefficient Mps1 Auto-Activation Due to a Weakened Mitotic Checkpoint and Lagging Chromosomes
Background Chromosomal instability (CIN), a feature widely shared by cells from solid tumors, is caused by occasional chromosome missegregations during cell division. Two of the causes of CIN areExpand
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FOXO4 transcriptional activity is regulated by monoubiquitination and USP7/HAUSP
FOXO (Forkhead box O) transcription factors are important regulators of cellular metabolism, cell-cycle progression and cell death. FOXO activity is regulated by multiple post-translationalExpand
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Collagens are functional, high affinity ligands for the inhibitory immune receptor LAIR-1
Collagens are the most abundant proteins in the human body, important in maintenance of tissue structure and hemostasis. Here we report that collagens are high affinity ligands for the broadlyExpand
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Regulation of Treg functionality by acetylation-mediated Foxp3 protein stabilization.
Regulatory T cells (Tregs) are a specific subset of lymphocytes that are critical for the maintenance of self-tolerance. Expression levels of the transcription factor Foxp3 have been causallyExpand
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Stabilization of the transcription factor Foxp3 by the deubiquitinase USP7 increases Treg-cell-suppressive capacity.
Stable Foxp3 expression is required for the development of functional regulatory T (Treg) cells. Here, we demonstrate that the expression of the transcription factor Foxp3 can be regulated throughExpand
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Regulation of histone H3K4 tri-methylation and PAF complex recruitment by the Ccr4-Not complex
Efficient transcription is linked to modification of chromatin. For instance, tri-methylation of lysine 4 on histone H3 (H3K4) strongly correlates with transcriptional activity and is regulated byExpand
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Mesenchymal stem cells induce resistance to chemotherapy through the release of platinum-induced fatty acids.
The development of resistance to chemotherapy is a major obstacle for lasting effective treatment of cancer. Here, we demonstrate that endogenous mesenchymal stem cells (MSCs) become activated duringExpand
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Quantitative profiling of oxylipins through comprehensive LC-MS/MS analysis: application in cardiac surgery
AbstractOxylipins, including eicosanoids, affect a broad range of biological processes, such as the initiation and resolution of inflammation. These compounds, also referred to as lipid mediators,Expand
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