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Schizophrenia is associated with elevated amphetamine-induced synaptic dopamine concentrations: evidence from a novel positron emission tomography method.
- A. Breier, T. Su, D. Pickar
- Biology, PsychologyProceedings of the National Academy of Sciences…
- 18 March 1997
In the clinical study, patients with schizophrenia compared with healthy volunteers had significantly greater amphetamine-related reductions in [11C]raclopride specific binding, providing direct evidence for the hypothesis of elevated Amphetamine-induced synaptic dopamine concentrations in schizophrenia.
Efficacy of olanzapine and olanzapine-fluoxetine combination in the treatment of bipolar I depression.
Olanzapine is more effective than placebo, and combined olanzapine-fluoxetine isMore effective than olanZapine and placebo in the treatment of bipolar I depression without increased risk of developing manic symptoms.
NMDA Receptor Function and Human Cognition: The Effects of Ketamine in Healthy Volunteers
Randomized, double-blind trial of olanzapine versus placebo in patients prodromally symptomatic for psychosis.
- T. McGlashan, R. Zipursky, A. Breier
- Medicine, PsychologyThe American journal of psychiatry
- 1 May 2006
The nearly significant differences suggest that olanzapine might reduce the conversion rate and delay onset of psychosis, and was efficacious for positive prodromal symptoms but induced weight gain.
Neuropsychological change in early phase schizophrenia during 12 months of treatment with olanzapine, risperidone, or haloperidol. The Canadian Collaborative Group for research in schizophrenia.
Olanzapine has some superior cognitive benefits relative to haloperidol and risperidone, and a larger sample replication study is necessary to confirm and generalize the observations of this study.
Convergent functional genomics of schizophrenia: from comprehensive understanding to genetic risk prediction
This work maps the genomic and biological landscape for schizophrenia, providing leads towards a better understanding of illness, diagnostics and therapeutics, and reveals the significant genetic overlap with other major psychiatric disorder domains, suggesting the need for improved nosology.
Efficacy of olanzapine in combination with valproate or lithium in the treatment of mania in patients partially nonresponsive to valproate or lithium monotherapy.
Compared with the use of valproate or lithium alone, the addition of olanzapine provided superior efficacy in the treatment of manic and mixed bipolar episodes.
Ketamine-Induced Exacerbation of Psychotic Symptoms and Cognitive Impairment in Neuroleptic-Free Schizophrenics
Efficacy of olanzapine in acute bipolar mania: a double-blind, placebo-controlled study. The Olanzipine HGGW Study Group.
Olanzapine demonstrated greater efficacy than placebo in the treatment of acute bipolar mania and was generally well tolerated.
Association of ketamine-induced psychosis with focal activation of the prefrontal cortex in healthy volunteers.
- A. Breier, A. Malhotra, D. Pinals, N. Weisenfeld, D. Pickar
- Medicine, PsychologyAmerican Journal of Psychiatry
Data suggest that the prefrontal cortex may be involved in mediating NMDA receptor-induced psychosis, and a change in one psychotic symptom, conceptual disorganization, was significantly related to prefrontal activation.