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Mathematical model of NF- κB regulatory module
TLDR
The two-feedback-loop regulatory module of nuclear factor kappaB (NF-kappaB) signaling pathway is modeled by means of ordinary differential equations and gives the predictions of the possible responses of whole kinetics to the change in the level of a given activator or inhibitor. Expand
The nuclear factor-kappaB-interleukin-6 signalling pathway mediating vascular inflammation.
  • A. Brasier
  • Medicine, Biology
  • Cardiovascular research
  • 1 May 2010
TLDR
New discoveries further the understanding for the important role of the NF-kappaB-IL-6 signalling pathway in the process of vascular inflammation. Expand
Retinoic Acid-Inducible Gene I Mediates Early Antiviral Response and Toll-Like Receptor 3 Expression in Respiratory Syncytial Virus-Infected Airway Epithelial Cells
TLDR
Findings indicate distinct temporal roles of RIG-I and TLR3 in mediating RSV-induced innate immune responses, which are coupled to distinct pathways controlling NF-κB activation. Expand
Vascular inflammation and the renin-angiotensin system.
TLDR
A molecular mechanism for a biological positive-feedback loop that explains how vascular inflammation can be self-sustaining through upregulation of the vessel wall Ang II tone is defined, suggesting that one mechanism by which RAS antagonists prevent atherosclerosis is by reducing vascular inflammation. Expand
MYH11 mutations result in a distinct vascular pathology driven by insulin-like growth factor 1 and angiotensin II.
TLDR
Data suggest that MYH11 mutations are likely to be specific to the phenotype of TAAD/PDA and result in a distinct aortic and occlusive vascular pathology potentially driven by IGF-1 and Ang II. Expand
Hungry bone syndrome: clinical and biochemical predictors of its occurrence after parathyroid surgery.
The hospital course of 218 consecutive patients with primary hyperparathyroidism admitted over a three-year period for parathyroidectomy at the Massachusetts General Hospital was reviewed toExpand
An adventitial IL-6/MCP1 amplification loop accelerates macrophage-mediated vascular inflammation leading to aortic dissection in mice.
TLDR
Results suggest that leukocyte-fibroblast interactions in the aortic adventitia potentiate IL-6 production, inducing local monocyte recruitment and activation, thereby promoting MCP-1 secretion, vascular inflammation, ECM remodeling, and aortIC destabilization. Expand
Mathematical model of NF-kappaB regulatory module.
TLDR
The two-feedback-loop regulatory module of nuclear factor kappaB (NF-kappaB) signaling pathway is modeled by means of ordinary differential equations and gives the predictions of the possible responses of whole kinetics to the change in the level of a given activator or inhibitor. Expand
The NF-κB regulatory network
TLDR
Although the noncanonical NF-κB pathway has been most clearly linked to control of adaptive immunity, recent intriguing studies have implicated this pathway in viral induced stress response and in the metabolic syndrome. Expand
Identification of Direct Genomic Targets Downstream of the Nuclear Factor-κB Transcription Factor Mediating Tumor Necrosis Factor Signaling*
TLDR
These studies systematically identify the direct NF-κB-dependent gene network downstream of TNF signaling, extending the knowledge of biological processes regulated by this pathway. Expand
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