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Characterization of the high-affinity monocarboxylate transporter MCT2 in Xenopus laevis oocytes.
TLDR
It is suggested that cells which express MCT2 preferentially use lactate and ketone bodies as energy sources, and could be inhibited by alpha-cyano-4-hydroxycinnamate, anion-channel inhibitors and flavonoids. Expand
Characterization of the monocarboxylate transporter 1 expressed in Xenopus laevis oocytes by changes in cytosolic pH.
TLDR
The basic kinetic properties of lactate transport in MCT1-expressing oocytes were determined by analysing the rates of intracellular pH changes under different conditions and were in agreement with the known properties of the transporter. Expand
Molecular Cloning of Mouse Amino Acid Transport System B0, a Neutral Amino Acid Transporter Related to Hartnup Disorder*
TLDR
A novel member of the Na+-dependent neurotransmitter transporter family (B0AT1) isolated from mouse kidney shows all properties of system B0, and the human homologue of this transporter is an excellent functional and positional candidate for Hartnup disorder. Expand
The Astroglial ASCT2 Amino Acid Transporter as a Mediator of Glutamine Efflux
TLDR
It is shown here that ASCT2, a variant of transport system ASC, is strongly expressed in rat astroglia-rich primary cultures but not in neuron-richPrimary cultures, and suggest a significant role of AS CT2 in glutamine efflux from astrocytes by obligatory exchange with extracellular amino acids. Expand
The heterodimeric amino acid transporter 4F2hc/y+LAT2 mediates arginine efflux in exchange with glutamine.
TLDR
Results indicated that arginine has the highest affinity for the intracellular binding site and that arkinine release may be the main physiological function of this transporter. Expand
The orphan transporter v7-3 (slc6a15) is a Na+-dependent neutral amino acid transporter (B0AT2).
TLDR
It is demonstrated that mouse v7-3 (slc6a15) encodes a transporter for neutral amino acids and was hence named B(0)AT2, which was Na+-dependent, Cl--independent and electrogenic, and a potential role in transporting neurotransmitter precursors and neuromodulators is proposed. Expand
Molecular cloning of the mouse IMINO system: an Na+- and Cl--dependent proline transporter.
TLDR
It is demonstrated that the mouse homologue of slc6a20 has all properties of the long-sought IMINO system, and the two homologues corresponding to the single human SLC6A20 gene are named XT3 and XT3s1 to indicate the tissue expression of the two genes. Expand
A protein complex in the brush‐border membrane explains a Hartnup disorder allele
TLDR
Coexpression of the Hartnup disorder causing mutation B0AT1(R240Q) showed reduced interaction with ACE2 and its renal paralogue collectrin, thereby explaining the onset of the disorder in individuals carrying this mutation. Expand
Deletion of Amino Acid Transporter ASCT2 (SLC1A5) Reveals an Essential Role for Transporters SNAT1 (SLC38A1) and SNAT2 (SLC38A2) to Sustain Glutaminolysis in Cancer Cells*
TLDR
It is shown that HeLa epithelial cervical cancer cells and 143B osteosarcoma cells express a set of glutamine transporters including SNAT1, SNAT2,SNAT2 (SLC38A2), SNAT4, LAT1, and ASCT2, and a combined targeted approach would inhibit growth of glutamines-dependent cancer cells. Expand
Regulation of the glutamine transporter SN1 by extracellular pH and intracellular sodium ions
TLDR
Determination of accumulation ratios at different driving forces were in agreement with an electroneutral 1Na+‐glutamine cotransport‐1H+ antiport, and inward currents that were observed during glutamine uptake were much smaller than expected for a stoichiometric cOTransport of charges. Expand
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