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Phosphate‐Dependent Regulation of MGP in Osteoblasts: Role of ERK1/2 and Fra‐1
Inorganic phosphate (Pi) and the matrix Gla protein (MGP) are key regulators of bone formation. We have recently shown that Pi upregulates MGP in growth plate chondrocytes, which may represent aExpand
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Directed differentiation of hematopoietic precursors and functional osteoclasts from human ES and iPS cells.
The directed differentiation of human pluripotent stem cells offers the unique opportunity to generate a broad spectrum of human cell types and tissues for transplantation, drug discovery, andExpand
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T Cell Costimulation Molecules CD80/86 Inhibit Osteoclast Differentiation by Inducing the IDO/Tryptophan Pathway
Costimulatory molecules CD80/CD86 suppress osteoclast differentiation by inducing indoleamine 2,3-dioxygenase. A Bone to Pick with the Immune System School children are often taught that bones areExpand
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Hypoxia-inducible factor-1α is a critical transcription factor for IL-10-producing B cells in autoimmune disease
Hypoxia-inducible factors (HIFs) are key elements for controlling immune cell metabolism and functions. While HIFs are known to be involved in T cells and macrophages activation, their functions in BExpand
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A6.4 Induction of TH2 cells and eosinophil by infection with nippostrongylus brasiliensis protects against rheumatoid arthritis
Background and Objective Infection with helminth triggers strong Th2 immune response, which modulates the development of systemic autoimmune diseases. The aim of this study was to investigate whetherExpand
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Fra-2/AP-1 controls adipocyte differentiation and survival by regulating PPARγ and hypoxia
Adipocyte cell number is a crucial factor for controlling of body weight and metabolic function. The regulation of adipocyte numbers in the adult organism is not fully understood but is considered toExpand
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The AP-1 transcription factor Fra1 inhibits follicular B cell differentiation into plasma cells
The authors regret that errors appeared in the original html and pdf versions of the paper. The heading to Figure 6 should read " Fra1 inhibits Blimp1 expression. " In the acknowledgements, grantsExpand
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Fra-2/AP-1 controls bone formation by regulating osteoblast differentiation and collagen production
Both the osteoblast-specific osteocalcin gene and collagen 1α2 are targets of the transcription factor Fra-2, which controls bone formation.
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Alterations of Sertoli cell activity in the long-term testicular germ cell death process induced by fetal androgen disruption.
Fetal androgen disruption, induced by the administration of anti-androgen flutamide (0.4, 2, and 10 mg/kg day) causes a long-term apoptosis in testicular germ cells in adult male rat offspring. OneExpand
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Osteoblast-specific expression of Fra-2/AP-1 controls adiponectin and osteocalcin expression and affects metabolism
Summary Recent studies have established that the skeleton functions as an endocrine organ affecting metabolism through the osteoblast-derived hormone osteocalcin (Ocn). However, it is not fullyExpand
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