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Physiology and Neurobiology of Stress and Adaptation: Central Role of the Brain
[PDF] [Full Text] [Abstract] , January 15, 2008; 105 (2): 751-756. PNAS J. W. Koo and R. S. Duman IL-1 is an essential mediator of the antineurogenic and anhedonic effects of stress [PDF] [FullExpand
Beneficial effects of moderate exercise on mice aging: survival, behavior, oxidative stress, and mitochondrial electron transfer.
TLDR
Moderate exercise, started at young age in mice, increased life span, decreased oxidative stress, and prevented the decline of cytochrome oxidase activity and behavioral performance at middle age but not at old age. Expand
Spermatic cord torsion, reactive oxygen and nitrogen species and ischemia-reperfusion injury.
TLDR
More investigations on the molecular mechanisms and the antioxidant status in testis are necessary to ascertain the contribution of ROS to the tissue damage produced by spermatic cord torsion in experimental animals and humans. Expand
The mitochondrial energy transduction system and the aging process.
  • A. Navarro, A. Boveris
  • Medicine, Biology
  • American journal of physiology. Cell physiology
  • 1 February 2007
TLDR
Dysfunctional mitochondria in aged rodents are characterized, besides decreased electron transfer and O(2) uptake, by an increased content of oxidation products of phospholipids, proteins and DNA, a decreased membrane potential, and increased size and fragility. Expand
Lipid Peroxidation: Chemical Mechanism, Biological Implications and Analytical Determination
© 2012 Repetto et al., licensee InTech. This is an open access chapter distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), whichExpand
Behavioral dysfunction, brain oxidative stress, and impaired mitochondrial electron transfer in aging mice.
TLDR
The cumulative toxic effects of oxyradicals are considered the molecular mechanism of the behavioral deficits observed on aging. Expand
Rat brain and liver mitochondria develop oxidative stress and lose enzymatic activities on aging.
TLDR
A subpopulation of brain mitochondria with increased size and fragility was differentiated in aging rats, whereas liver showed a homogeneous mitochondrial population, as assayed by mitochondrial marker enzyme activities in the postmitochondrial supernatant. Expand
Comparison of Lipid Peroxidation and Myocardial Damage Induced by Adriamycin and 4′-Epiadriamycin in Mice
TLDR
The data showing that 4′-ADM lacks a statistically significant effect in increasing heart peroxidation as compared to ADM may explain its lower myocardial toxicity. Expand
Regulation of Mitochondrial Respiration by Oxygen and Nitric Oxide
TLDR
Recent research indicates that NO participates in redox reactions in the mitochondrial matrix that regulate the intramitochondrial steady state concentration of NO itself and other reactive species such as superoxide radical (O2−) and peroxynitrite (ONOO−). Expand
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