• Publications
  • Influence
Hydroperoxide metabolism in mammalian organs.
The mitochondrial generation of hydrogen peroxide. General properties and effect of hyperbaric oxygen.
TLDR
It is postulated that in addition to the well-known flavin reaction, formation of H( 2)O(2) may be due to interaction with an energy-dependent component of the respiratory chain at the cytochrome b level. Expand
The cellular production of hydrogen peroxide.
TLDR
The cytochrome c peroxidase assay is suitable for use with subcellular fractions from tissue homogenates as well as with pure enzyme systems to measure H(2)O( 2) generation and can be made on the basis of the rates with the isolated fractions under physiological conditions. Expand
Role of ubiquinone in the mitochondrial generation of hydrogen peroxide.
TLDR
Parallel measurements of H2O2 production, succinate dehydrogenase and succinate-cytochrome c reductase activities show that peroxide generation by ubiquin one-supplemented membranes is a monotonous function of the reducible ubiquinone content, whereas the other two measured activities reach saturation at relatively low concentrations of reducible quinone. Expand
Production of superoxide radicals and hydrogen peroxide by NADH-ubiquinone reductase and ubiquinol-cytochrome c reductase from beef-heart mitochondria.
TLDR
Evidence for the role of ubiquinone as peroxide generator is provided by the generation of O 2 − and H 2 O 2 during autoxidation of quinols. Expand
Nitric oxide inhibits electron transfer and increases superoxide radical production in rat heart mitochondria and submitochondrial particles.
TLDR
Cytochrome spectra and decreased enzymatic activities in the presence of .NO are consistent with a multiple inhibition of mitochondrial electron transfer at cytochrome oxidase and at the ubiquinone-cytochrome b region of the respiratory chain, the latter leading to the increased O2- production. Expand
Determination of the production of superoxide radicals and hydrogen peroxide in mitochondria.
  • A. Boveris
  • Chemistry, Medicine
  • Methods in enzymology
  • 1984
TLDR
Mitochondrial O 2 - production is pH dependent and increases toward the alkaline region, and effective inhibitors of Mn-superoxide dismutase are not known, and matrical superoxide dismUTase is usually removed by the repetitive washing of submitochondrial particles obtained by sonication or by other means. Expand
Hydroperoxide-initiated chemiluminescence: an assay for oxidative stress in biopsies of heart, liver, and muscle.
TLDR
Liver and heart homogenates were subjected to in vitro oxidative stresses such as supplementation with organic hydroperoxide or with enzymatic systems generating superoxide anion or hydrogen peroxide and chemiluminescence was higher in the poststress samples than in the control ones. Expand
Mitochondrial production of superoxide radical and hydrogen peroxide.
  • A. Boveris
  • Chemistry, Medicine
  • Advances in experimental medicine and biology
  • 1977
TLDR
It was realized that this assay could be easily interfered by endogenous hydrogen donor of the horseradish peroxidase and by exogenous hydrogen donors in the mitochondrial preparations, and consequently, an alternative method was developed. Expand
Production of Nitric Oxide by Mitochondria*
TLDR
It is demonstrated that mitochondria are a source of NO⋅, the production of which may effect energy metabolism, O2consumption, and O2 free radical formation. Expand
...
1
2
3
4
5
...