Susceptibility to conditioned place preference induced by addictive drugs in mice of the C57BL/6 and DBA/2 inbred strains
- C. Orsini, A. Bonito-Oliva, D. Conversi, S. Cabib
- Psychology, BiologyPsychopharmacology
- 28 April 2005
The results demonstrate that C57 and DBA mice differ in their sensitivity to cocaine- and morphine-induced CPP and suggest that the two strains differ in sensitivity to the positive incentive properties of drugs of abuse.
L-DOPA-Induced Dyskinesia and Abnormal Signaling in Striatal Medium Spiny Neurons: Focus on Dopamine D1 Receptor-Mediated Transmission
- M. Feyder, A. Bonito-Oliva, G. Fisone
- BiologyFrontiers in Behavioral Neuroscience
- 24 October 2011
This review focuses on the abnormalities in signaling affecting the D1R-expressing MSNs and on their potential relevance for the design of novel anti-dyskinetic therapies.
Update on Alzheimer's Disease Therapy and Prevention Strategies.
- W. V. Graham, A. Bonito-Oliva, T. Sakmar
- BiologyAnnual Review of Medicine
- 18 January 2017
The main focus of this review is to summarize the most recent basic biology, biochemistry, and pharmacology that serve as a foundation for more than 50 active advanced-phase clinical trials for AD prevention and therapy.
A mouse model of non-motor symptoms in Parkinson's disease: focus on pharmacological interventions targeting affective dysfunctions
- A. Bonito-Oliva, D. Masini, G. Fisone
- Psychology, BiologyFrontiers in Behavioral Neuroscience
- 27 August 2014
It is proposed that the anti-depressive and anxiolytic action of reboxetine is mediated by promoting dopamine transmission through blockade of dopamine uptake from residual noradrenergic terminals.
Haloperidol Regulates the State of Phosphorylation of Ribosomal Protein S6 via Activation of PKA and Phosphorylation of DARPP-32
- E. Valjent, J. Bertran-Gonzalez, G. Fisone
- Biology, ChemistryNeuropsychopharmacology
- 3 August 2011
It is found that haloperidol increases the phosphorylation of rpS6 at the dual site Ser235/236, which is involved in the regulation of mRNA translation, and PKA is identified as a major rPS6 kinase in neuronal cells, suggesting that regulation of protein synthesis through rp S6 may be a potential target of antipsychotic drugs.
Phosphodiesterase 10A controls D1-mediated facilitation of GABA release from striato-nigral projections under normal and dopamine-depleted conditions
- D. Mango, A. Bonito-Oliva, N. Mercuri
- BiologyNeuropharmacology
- 31 January 2014
Activation of metabotropic glutamate 4 receptors decreases L-DOPA-induced dyskinesia in a mouse model of Parkinson's disease.
- S. Lopez, A. Bonito-Oliva, S. Pallottino, F. Acher, G. Fisone
- Biology, PsychologyJournal of Parkinson's Disease
- 2011
Results indicate that co-administration of LSP1-2111 may improve the efficacy of standard L-DOPA therapy by attenuating its liability for dyskinesia.
Higher free d-aspartate and N-methyl-d-aspartate levels prevent striatal depotentiation and anticipate l-DOPA-induced dyskinesia
- F. Errico, A. Bonito-Oliva, A. Usiello
- Biology, PsychologyExperimental Neurology
- 1 December 2011
Understanding cognitive deficits in Parkinson's disease: lessons from preclinical animal models.
- N. Solari, A. Bonito-Oliva, G. Fisone, R. Brambilla
- Biology, PsychologyLearning & memory (Cold Spring Harbor, N.Y.)
- 1 October 2013
An overview on the cognitive symptoms occurring in early PD patients is provided and the rodent and nonhuman primate models so far available for the study of discriminative and spatial memory attention and learning abilities related to this pathological condition are focused on.
Role of Aberrant Striatal Dopamine D1 Receptor/cAMP/Protein Kinase A/DARPP32 Signaling in the Paradoxical Calming Effect of Amphetamine
- F. Napolitano, A. Bonito-Oliva, A. Usiello
- Biology, PsychologyJournal of Neuroscience
- 18 August 2010
The results suggest that the paradoxical motor calming effect induced by these drugs in DAT-CI mutants depends on selective aberrant phasic activation of D1R/cAMP/PKA/DARPP32 signaling in response to increased striatal extracellular dopamine levels.
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