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Cyclo‐oxygenase‐2 mediates P2Y receptor‐induced reactive astrogliosis
Excessive cyclo‐oxygenase‐2 (COX‐2) induction may play a role in chronic neurological diseases characterized by inflammation and astrogliosis. We have previously identified an astroglial receptor forExpand
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Leukotriene D4-induced activation of smooth-muscle cells from human bronchi is partly Ca2+-independent.
Cysteine-containing leukotrienes (cysteinyl-LTs) are potent bronchoconstrictors and play a key role in asthma. We found that histamine and LTD4 markedly constrict strips of human bronchi (HB) withExpand
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Nitric oxide modulation of transcellular biosynthesis of cys‐leukotrienes in rabbit leukocyte‐perfused heart
We have studied the role of nitric oxide (NO) in the regulation of the transcellular biosynthesis of sulphidopeptide leukotrienes (cys‐LT) generated upon neutrophil‐vascular wall interactions andExpand
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COX-2 lack of function in hypoxia-induced ocular surface inflammation.
Injury to the ocular surface increases corneal epithelial production of cyclooxygenase (COX)-derived eicosanoids but this increase correlates poorly to the inflammatory sequelae. Moreover,Expand
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Cyclooxygenase-2 and synthesis of PGE2 in human bronchial smooth-muscle cells.
The purpose of this study was to determine the mechanism of enhanced prostaglandin synthesis in cultured human bronchial smooth-muscle cells challenged with interleukin-1 beta (IL-1 beta). Cells wereExpand
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Effect of endogenous and exogenous prostaglandin E(2) on interleukin-1 beta-induced cyclooxygenase-2 expression in human airway smooth-muscle cells.
  • A. Bonazzi, M. Bolla, +10 authors A. Sala
  • Biology, Medicine
  • American journal of respiratory and critical care…
  • 1 December 2000
We studied the effect of endogenous and exogenous prostaglandin E(2) (PGE(2)), a metabolite of arachidonic acid through the cyclooxygenase (COX) pathway, on interleukin (IL)-1 beta-induced COX-2Expand
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Monoclonal anti-CD18 antibody prevents transcellular biosynthesis of cysteinyl leukotrienes in vitro and in vivo and protects against leukotriene-dependent increase in coronary vascular resistance
BACKGROUND Cysteinyl leukotrienes (cys-LT) can constrict small and large vessels and increase vascular permeability. Formation of cys-LT arising from polymorphonuclear leukocytes (PMNL) andExpand
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The polymorphonuclear leukocyte: a cell tuned for transcellular biosynthesis of cys-leukotrienes.
Sulfidopeptide leukotrienes (cysLT) are potent vasoactive mediators that can constrict coronary vessels and alter caliber of the microcirculation. They can be formed "in situ" via a peculiar type ofExpand
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Leukotriene D 4-Induced Activation of Smooth-Muscle Cells From Human Bronchi Is Partly Ca 2 1-Independent
Cysteine-containing leukotrienes (cysteinyl-LTs) are potent bronchoconstrictors and play a key role in asthma. We found that histamine and LTD 4 markedly constrict strips of human bronchi (HB) withExpand
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