• Publications
  • Influence
Guidelines for the conduct of clinical trials for spinal cord injury as developed by the ICCP panel: spontaneous recovery after spinal cord injury and statistical power needed for therapeutic
The International Campaign for Cures of Spinal Cord Injury Paralysis (ICCP) supported an international panel tasked with reviewing the methodology for clinical trials in spinal cord injury (SCI), andExpand
  • 551
  • 22
  • PDF
A phase 3 trial of extended release oral dalfampridine in multiple sclerosis
A previous phase 3 study showed significant improvement in walking ability in multiple sclerosis (MS) patients treated with oral, extended‐release dalfampridine (4‐aminopyridine) 10mg twice daily.Expand
  • 298
  • 20
  • PDF
Delayed demyelination and macrophage invasion: a candidate for secondary cell damage in spinal cord injury.
  • A. Blight
  • Medicine
  • Central nervous system trauma : journal of the…
  • 1985
Recent studies of the chronic morphology and physiology of experimental spinal cord injury (SCI) in the cat are reviewed and their conclusions outlined. In particular, variations in chronicExpand
  • 303
  • 14
Dose comparison trial of sustained-release fampridine in multiple sclerosis
Objective: To examine the efficacy and safety of three different doses of sustained-release fampridine in people with multiple sclerosis (MS). Method: This multicenter, randomized, double-blind,Expand
  • 146
  • 11
Fampridine-SR in multiple sclerosis: a randomized, double-blind, placebo-controlled, dose-ranging study
Objective To determine the safety of sustained-release 4-aminopyridine in subjects with mutiple sclerosis (MS) and to examine dose-related efficacy up to 40 mg twice daily. Method Multicenter,Expand
  • 139
  • 11
Morphometric analysis of experimental spinal cord injury in the cat: The relation of injury intensity to survival of myelinated axons
The pattern of axonal destruction and demyelination that occurs in experimental contusion injury of cat thoracic spinal cord was studied by line sampling of axons in 1 micron thick plastic sectionsExpand
  • 265
  • 9
Effects of silica on the outcome from experimental spinal cord injury: Implication of macrophages in secondary tissue damage
A model of spinal cord trauma in guinea-pigs, using lateral compression to a set thickness, produces a delayed functional loss at one to two days, followed by a partial recovery over several weeks,Expand
  • 184
  • 9
Chondroitinase ABCI improves locomotion and bladder function following contusion injury of the rat spinal cord.
Chondroitin sulfate proteoglycans are synthesized and deposited in the spinal cord following injury. These proteoglycans may restrict regeneration and plasticity and contribute to the limitedExpand
  • 176
  • 9
Morphometric analysis of a model of spinal cord injury in guinea pigs, with behavioral evidence of delayed secondary pathology
  • A. Blight
  • Medicine
  • Journal of the Neurological Sciences
  • 1 June 1991
A model of spinal cord trauma in guinea pigs is described, based on the concept of compression to a set thickness, as an alternative to compression or contusion with a set force or displacement. TheExpand
  • 149
  • 8
Computer simulation of action potentials and afterpotentials in mammalian myelinated axons: The case for a lower resistance myelin sheath
  • A. Blight
  • Biology, Medicine
  • Neuroscience
  • 1 May 1985
Depolarizing afterpotentials, recorded in peripheral nerves [Barrett and Barrett (1982) J. Physiol., Lond. 323, 117-144] and spinal axons [Blight and Someya (1985) Neuroscience 15, 1-12], have beenExpand
  • 116
  • 8