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Ezh1 and Ezh2 maintain repressive chromatin through different mechanisms.
TLDR
It is reported that the mammalian homologs Ezh1 and Ezh2 form similar PRC2 complexes but exhibit contrasting repressive roles, and Ez h1 knockdown was ineffectual on global H3K27me2/3 levels, while Ezh 1 directly and robustly represses transcription from chromatinized templates and compacts chromatin in the absence of the methyltransferase cofactor SAM. Expand
XBP1 controls diverse cell type- and condition-specific transcriptional regulatory networks.
TLDR
A core group of genes involved in constitutive maintenance of ER function in all cell types and tissue- and condition-specific targets are identified and a cadre of unexpected targets that link XBP1 to neurodegenerative and myodegenerative diseases, as well as to DNA damage and repair pathways are identified. Expand
An initial blueprint for myogenic differentiation.
TLDR
It is found that MRFs play an unexpectedly wide-ranging role in directing the assembly and usage of the neuromuscular junction and these factors also prepare myoblasts to respond to diverse types of stress. Expand
Retinoblastoma tumor suppressor protein–dependent methylation of histone H3 lysine 27 is associated with irreversible cell cycle exit
TLDR
It is demonstrated that pRb effects permanent cell cycle exit in part by maintaining trimethylation of histone H3 lysine 27 (H3K27) on cell cycle genes, which distinguish two distinct chromatin-based regulatory mechanisms that lead to terminal differentiation. Expand
Cooperation between myogenic regulatory factors and SIX family transcription factors is important for myoblast differentiation
TLDR
It is reported that SIX factors cooperate with the members of the MRF family to activate gene expression during myogenic differentiation, and that their function is essential to this process. Expand
A common set of gene regulatory networks links metabolism and growth inhibition.
TLDR
These studies provide insights into E2F regulatory circuitry, suggest how factor occupancy can predict the expression signature of a given target gene, and reveal pathways deregulated in human tumors. Expand
Constructing transcriptional regulatory networks.
TLDR
The properties of transcriptional regulatory networks and the rapidly evolving approaches that will enable the elucidation of their structure and dynamic behavior are reviewed. Expand
UTX mediates demethylation of H3K27me3 at muscle-specific genes during myogenesis
TLDR
A two‐step mechanism for UTX‐mediated demethylation at muscle‐specific genes during myogenesis is demonstrated, whereby removal of repressive H3K27me3 marks by UTX occurs through targeted recruitment followed by spreading across the gene. Expand
Regulation of the Human Cyclin-dependent Kinase Inhibitor p18 INK4c by the Transcription Factors E2F1 and Sp1*
TLDR
It is concluded that E2F proteins and Sp1 play an important role in the control of p18 expression and can synergistically enhance the activity of the proximal p18 promoter. Expand
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