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Influence of the aminoacyl‐tRNA synthetase inhibitors and the diadenosine‐5'‐tetraphosphate phosphonate analogues on the catalysis of diadenosyl oligophosphates formation
Well‐known aminoacyl‐tRNA synthetase (ARSase) inhibitors, namely the analogues of amino acids and aminoacyl adenylates (aminoalkyl‐ and aminophosphonyl adenylates with K i ⋍ 0.1 μM) as well as theExpand
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Inhibition of pigeon breast muscle alpha-ketoglutarate dehydrogenase by phosphonate analogues of alpha-ketoglutarate.
Succinylphosphonate (SP) is a powerful inhibitor of alpha-ketoglutarate dehydrogenase (KGD). Methylation of the phosphonate reduces its inhibitory effect. The complex of KGD with SP undergoes aExpand
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Phosphonate analogues of diadenosine 5',5'''-P1,P4-tetraphosphate as substrates or inhibitors of procaryotic and eucaryotic enzymes degrading dinucleoside tetraphosphates.
The substrate specificity of procaryotic and eucaryotic AppppA-degrading enzymes was investigated with phosphonate analogues of diadenosine 5',5'''-P1,P4-tetraphosphate (AppppA). App(CH2)ppA (I),Expand
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Succinyl phosphonate inhibits α‐ketoglutarate oxidative decarboxylation, catalyzed by α‐ketoglutarate dehydrogenase complexes from E. coli and pigeon breast muscle
Effects of a set of α‐ketoglutarate phosphoanalogues on the activity of α‐ketoglutarate dehydrogenase (EC 1.2.4.2) complexes from E. coli and pigeon breast muscle, as well as on α‐ketoglutarateExpand
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Inhibition of pigeon breast muscle α‐ketoglutarate dehydrogenase by phosphonate analogues of α‐ketoglutarate
Succinylphosphonate (SP) is a powerful inhibitor or α‐ketoglutarate dehydrogenase (KGD). Methylation of the phosphonate reduces its inhibitory effect. The complex of KGD with SP undergoes aExpand
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Transition‐state analogues of aminoacyl adenylates
2.3. Determination of synthetase activity The activity of synthetases in the ATP-PP, exchange reaction was determined in the conditions of [8]. Samples were analysed as in [5]. Aminoacylation of tRNAExpand
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Succinyl phosphonate inhibits alpha-ketoglutarate oxidative decarboxylation, catalyzed by alpha-ketoglutarate dehydrogenase complexes from E. coli and pigeon breast muscle.
Effects of a set of alpha-ketoglutarate phosphoanalogues on the activity of alpha-ketoglutarate dehydrogenase (EC 1.2.4.2) complexes from E. coli and pigeon breast muscle, as well as onExpand
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Steel for valves in marine engines
ConclusionSteel 2Kh20N9V2GSM proposed for manufacturing heavily stressed valves, is superior to the previously used steel 2Kh18N8V2, since it is less susceptible to differences in grain size and hasExpand
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