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Promoter proximal splice sites enhance transcription.
TLDR
It is shown here that splicing signals can have a direct role in enhancing gene transcription, based on both nuclear run-on and direct image analysis and establishes that mRNA processing and transcription are tightly coupled mechanisms. Expand
Biomarkers in acute respiratory distress syndrome
TLDR
The article provides an overview of efforts to identify and validate biomarkers in acute respiratory distress syndrome (ARDS) and provides a framework for future investigation. Expand
Epigenetic therapy in urologic cancers: an update on clinical trials
TLDR
The most frequently used epigenetic drugs were histone deacetylase inhibitors followed by antisense oligonucleotides, DNA methyltransferase inhibitors and histone demethylase inhibitors, the last of which is only being tested in prostate cancer. Expand
Homologous gene sequences mediate transcription-domain formation
TLDR
Investigating plasmid TDs as a model for gene recruitment concludes that recruitment into TDs is an active process that is driven by homologies between transcribed sequences and becomes saturated at high copy numbers. Expand
Twenty articles that critical care clinicians should read about COVID-19
TLDR
20 papers that are of particular relevance to the critical care clinician are highlighted, divided into four broad topics: manifestations of severe COVID19 disease, pharmacological therapy for COVID-19, ventilatory support for CO VID-19 acute respiratory distress syndrome (ARDS), and healthcare system and worker stress. Expand
Roadmap of DNA methylation in breast cancer identifies novel prognostic biomarkers
TLDR
368 DNA methylation changes that characterize breast cancer tumor tissue are identified, of which 209 are associated with genes that are differentially-expressed in the same samples, which shows promise as diagnostic and prognostic markers in breast cancer as well as other cancer types. Expand
Epigenetics of Sepsis
TLDR
This review examines data from in vitro studies, animal studies, and the existing human sepsis studies in epigenetics to demonstrate that epigenetic mechanisms are likely central to the pathogenesis of sepsi and that epigenetics therapies may have potential in the treatment ofsepsis and its associated organ failures. Expand
Epigenetic Profiling in Severe Sepsis: A Pilot Study of DNA Methylation Profiles in Critical Illness.
TLDR
DNA methylation marks may provide important causal and potentially biomarker information in critically ill patients with sepsis and be associated with clinical traits including severity of illness, need for vasopressors, and length of stay. Expand
Epigenetic Profiling in Severe Sepsis: A Pilot Study of DNA Methylation Profiles in Critical Illness.
TLDR
DNA methylation marks may provide important causal and potentially biomarker information in critically ill patients with sepsis and be associated with clinical traits including severity of illness, need for vasopressors, and length of stay. Expand
How the COVID-19 pandemic will change the future of critical care
TLDR
The COVID-19 pandemic has highlighted key elements of emergency preparedness, including having national or regional strategic reserves of personal protective equipment, intensive care unit (ICU) devices, consumables and pharmaceuticals, as well as effective supply chains and efficient utilization protocols. Expand
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