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Lipoic acid - the drug of the future?
Numerous experimental and clinical studies proved efficiency of treatment with lipoic acid-containing drugs in diseases, in which pro- and antioxidant balance is disrupted (diabetes,Expand
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  • Open Access
[The different aspects of the biological role of glutathione].
Glutathione plays a key role in maintaining a physiological balance between prooxidants and antioxidants, crucial for the life and death of a cell. Glutathione occurs in the human body in severalExpand
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  • Open Access
The role of lipoic acid in prevention of nitroglycerin tolerance.
Besides other organic nitrates, nitroglycerin (glyceryl trinitrate; GTN) has been used to treat acute heart failure particularly due to ischemic heart disease. However, one of serious clinicalExpand
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Allyl disulfide as donor and cyanide as acceptor of sulfane sulfur in the mouse tissues.
Cytoplasm of mammalian glial cells was reported to contain Gomori-positive cytoplasmic granulation (GPCG), whose biological role is unknown. The present study attempted to discover conditionsExpand
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  • Open Access
Biological actions of lipoic acid associated with sulfane sulfur metabolism.
This work aimed to investigate the effect of lipoic acid (LA) on sulfane sulfur (S(*)) level and rhodanese activity in rat tissues. In vitro studies conduced so far have indicated that dihydrolipoicExpand
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  • Open Access
Effects of aspirin on the levels of hydrogen sulfide and sulfane sulfur in mouse tissues.
This study was designed to investigate the effect of aspirin (ASA) on anaerobic cysteine metabolism, which yields sulfane sulfur-containing compounds and hydrogen sulfide (H(2)S), in mouse liver andExpand
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  • Open Access
The effect of the uremic toxin cyanate (CNO−) on anaerobic cysteine metabolism and oxidative processes in the rat liver: a protective effect of lipoate
Chronic renal failure (CRF) patients have an increased plasma level of urea, which can be a source of cyanate. This compound can cause protein carbamoylation thereby changing biological activity ofExpand
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Diet induced ruminal papillae development in neonatal calves not correlating with rumen butyrate
The objective of this study was to investigate the development of rumen mucosa and the level of plasma IGF-1 in calves induced by different amounts and types of milk replacers and solid diet.Expand
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  • Open Access
The Effect of Lipoic Acid on Cyanate Toxicity in Different Structures of the Rat Brain
Cyanate is formed mostly during nonenzymatic urea biodegradation. Its active form isocyanate reacts with protein –NH2 and –SH groups, which changes their structure and function. The present studiesExpand
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  • Open Access
The effect of uremic toxin cyanate (OCN--) on anaerobic sulfur metabolism and prooxidative processes in the rat kidney: A protective role of lipoate
Cyanate and its active form isocyanate are formed mainly in the process of nonenzymatic urea biodegradation. Cyanate is capable of protein S- and N-carbamoylation, which can affect their activity.Expand
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