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The GABAB receptor interacts directly with the related transcription factors CREB2 and ATFx.
TLDR
It is demonstrated that receptor stimulation results in activation of transcription from a CREB2 responsive reporter gene, which is unique among Family C G protein-coupled receptors and, in the case of the GABA(B) receptor andCREB2, may play a role in long-term changes in the nervous system.
The putative cannabinoid receptor GPR55 plays a role in mechanical hyperalgesia associated with inflammatory and neuropathic pain
TLDR
Data suggest that the manipulation of GPR55 may have therapeutic potential in the treatment of both inflammatory and neuropathic pain.
GABAB receptor isoforms GBR1a and GBR1b, appear to be associated with pre‐ and post‐synaptic elements respectively in rat and human cerebellum
TLDR
The differential distribution of Gbr1a and GBR1b mRNA splice variants for GABAB receptors suggests a possible association of GBR 1a andGBR 1b with pre‐ and post‐synaptic elements respectively.
GABA(B) receptor heterodimer-component localisation in human brain.
TLDR
The results suggest the widespread distribution of GABA(B) receptors in human brain, and that GABA( B) receptors GBR1 and GBR2 can exist in the same cell, and therefore may function as a heterodimer in the human brain.
Novel histamine H3 receptor antagonists GSK189254 and GSK334429 are efficacious in surgically-induced and virally-induced rat models of neuropathic pain
TLDR
It is shown for the first time that chronic oral administration of selective H3 antagonists is effective in reversing neuropathic hypersensitivity in disease‐related models, and that specific H3 receptor binding sites are present in the human DRG and dorsal horn of the spinal cord.
Advances in the molecular understanding of GABAB receptors
TLDR
This review discusses the most recent findings in the rapidly expanding field of GABA(B) receptor research, and includes a summary of all splice variants of both receptor subunits identified to date.
Comparative cellular distribution of GABAA and GABAB receptors in the human basal ganglia: Immunohistochemical colocalization of the α1 subunit of the GABAA receptor, and the GABABR1 and GABABR2
TLDR
The results of this study provide the morphological basis for GABAergic transmission within the human basal ganglia and provides evidence that GABA acts through both GABAA and GABAB receptors.
Activation of the alpha7-nicotinic acetylcholine receptor reverses complete freund adjuvant-induced mechanical hyperalgesia in the rat via a central site of action.
TLDR
These studies provide good rationale for the utility of selective, central nervous system penetrant agonists at the alpha(7)-nicotinic receptor for the treatment of inflammatory pain.
GABAB receptor protein and mRNA distribution in rat spinal cord and dorsal root ganglia
TLDR
Evidence is provided to support the presence of metabotropic receptors for GABA, GABAB, on primary afferent terminals in mammalian spinal cord in the rat and show that the GABAB receptor subunits GABAB1 and GABAB2 mRNA and the corresponding subunit proteins are present in the spinal cord and dorsal root ganglion.
Cellular Prion Protein Mediates the Disruption of Hippocampal Synaptic Plasticity by Soluble Tau In Vivo
TLDR
It is reported that certain soluble forms of tau selectively disrupt synaptic plasticity in the live rat hippocampus and shown that monoclonal antibodies to cellular prion protein abrogate the impairment of long-term potentiation caused both by recombinant and Alzheimer's disease brain-derived soluble tau.
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