• Publications
  • Influence
Membrane anchorage brings about fusogenic properties in a short synthetic peptide.
TLDR
Data indicate that wae 11-induced fusion proceeds according to a model consistent with the stalk-pore hypothesis for membrane fusion, and it would appear that hydrophobic interactions facilitate the fusion event, possibly involving (partial) peptide penetration. Expand
Peptides and Membrane Fusion: Towards an Understanding of the Molecular Mechanism of Protein-Induced Fusion
TLDR
The application of peptides as a model system to understand the molecular details of membrane fusion will be discussed in detail and structure-function relationships will be revealed, particularly in the context of protein-induced membrane perturbations and bilayer-to-nonbilayer transition underlying the mechanism of fusion. Expand
Correlation between inhibition of cytoskeleton proteolysis and anti-vesiculation effect of calpeptin during A23187-induced activation of human platelets: are vesicles shed by filopod fragmentation?
TLDR
It is suggested that the cytoskeleton proteolysis, and more specifically filamin proteolytic activity, induced bloating of filopod surfaces, thus facilitating fragmentation of filipod into vesicles. Expand
A new cationic liposome encapsulating genetic material. A potential delivery system for polynucleotides.
TLDR
The addition of a biologically degradable cationic phospholipid, dipalmitoyl-L-alpha-phosphatidylethanolamine covalently coupled to L-lysine, in a standard liposome formulation allowed us to obtain vesicles with high entrapment of various polynucleotides. Expand
Interaction between spin-labeled acyl-coenzyme A and the mitochondrial adenosine diphosphate carrier.
TLDR
The results suggest that spin-labeled long-chain acylCoA added to mitochondria binds by its polar moiety to the ADP carrier, suggesting that the bulk of the label is also present in the lipid phase of the membrane. Expand
Effect of benzyl alcohol on phospholipid transverse mobility in human erythrocyte membrane.
TLDR
All the effects of benzyl alcohol can be described as an accumulation of labeled phosphatidylethanolamine in the inner leaflet, leading to an energy-consuming specific increase in aminophospholipid translocase activity, in addition to a slow and passive bidirectional flux of all phospholipids at 37 degrees C. Expand
Protein-induced Fusion Can Be Modulated by Target Membrane Lipids through a Structural Switch at the Level of the Fusion Peptide*
TLDR
Observations in biological fusion systems together with the model studies suggest that distinct lipids in target membranes provide a means for regulating membrane fusion by causing a reversible secondary structure switch of the fusion peptides. Expand
Lipid headgroup spacing and peptide penetration, but not peptide oligomerization, modulate peptide-induced fusion.
TLDR
Evidence is presented indicating that clustering is an accompanying event rather than a prerequisite for fusion, and the notion that various biologically relevant fusion phenomena are accompanied by protein clustering and the specific PC-species-dependent regulation of membrane fusion is emphasized. Expand
Kinetics of phospholipid transfer between liposomes (neutral or negatively charged) and high-density lipoproteins: a spin-label study of early events.
TLDR
The results agree most convincingly with a mechanism in which the diffusion of phospholipids into the HDL-endogenous lipids is the limiting step, occurring as a two-step process, and a negative charge effect on the lipid transfer rates and yields. Expand
Involvement of ATP-dependent Pseudomonas exotoxin translocation from a late recycling compartment in lymphocyte intoxication procedure.
TLDR
It is concluded that PE translocation from a late receptor recycling compartment is implicated in the lymphocyte intoxication procedure, and exposure to acidic pH is a prerequisite for PE membrane traversal. Expand
...
1
2
3
4
5
...