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Analysis of the karyotypes of four species of the Leptynia attenuata complex (Insecta Phasmatodea)
SUMMARYKaryotypes of several bisexual populations of the Leptynia attenuata complex were analysed. This complex includes four karyotypically differentiated taxa: Leptynia attenuata s.str., LeptyniaExpand
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Mutational landscape of primary, metastatic, and recurrent ovarian cancer reveals c-MYC gains as potential target for BET inhibitors
Significance Ovarian cancer has the propensity for early dissemination of microscopic metastases, making early detection challenging. Development of treatments for patients with advanced/recurrentExpand
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Serum miRNAs Expression and SNAP-25 Genotype in Alzheimer’s Disease
MicroRNAs (miRNAs) are small non-coding RNAs that control gene expression by binding their 3′ untranslated region (3′UTR) region; these molecules play a fundamental role in several pathologies,Expand
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Karyological studies of mediterranean stick-insects belonging to the genera Clonopsis and Leptynia (Insecta Phasmatodea)
SUMMARYKaryotypes of three species of Clonopsis and of various populations of Leptynia hispanica and L. attenuata complexes were analyzed. The taxonomic status of the latter complexes is stillExpand
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Modification of sialidase levels and sialoglycoconjugate pattern during erythroid and erytroleukemic cell differentiation
Glycosphingolipids and glycoproteins play pivotal roles in the complex series of events governing cell adhesion and signal transduction. Aberrant glycosilation, typical of tumor cells, represents aExpand
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A novel multiple biomarker panel for the early detection of high-grade serous ovarian carcinoma.
INTRODUCTION Since the majority of patients are diagnosed at an advanced stage, ovarian cancer remains the most lethal gynecologic malignancy. There is no single biomarker with the sensitivity andExpand
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PI3K oncogenic mutations mediate resistance to afatinib in HER2/neu overexpressing gynecological cancers.
OBJECTIVE Aberrant expression of HER2/neu and PIK3CA gene products secondary to amplification/mutations are common in high-grade-serous-endometrial (USC) and ovarian-cancers (HGSOC). Because scantExpand
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Whole-exome sequencing of cervical carcinomas identifies activating ERBB2 and PIK3CA mutations as targets for combination therapy
Significance The development of novel, effective treatments for patients with advanced/recurrent cervical cancer remains an unmet medical need. Using whole-exome sequencing, we identified multipleExpand
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Inhibition of BET Bromodomain Proteins with GS-5829 and GS-626510 in Uterine Serous Carcinoma, a Biologically Aggressive Variant of Endometrial Cancer
Purpose: Uterine serous carcinoma (USC) is a rare and aggressive variant of endometrial cancer. Whole-exome sequencing (WES) studies have recently reported c-Myc gene amplification in a large numberExpand
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Circulatory miR-223-3p Discriminates Between Parkinson’s and Alzheimer’s Patients
MiR-223-3p is involved in the regulation of a broad range of cellular processes and in many types of pathological processes as cancer, autoimmune and inflammatory diseases. MiR-223-3p has beenExpand
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